(APD) in castrated male and female rabbits. Moreover, castration reverses the normal sex differences in drug-sensitivity: orchiectomy prolongs APD and increases the incidence of IKr-blocker induced early afterdepolarizations (EAD), while ovariectomy reduces drug-induced APD prolongation and EADs [25]...
(8,9) In general, a drug that prolongs the QT interval by 10 ms or more (its central tendency of effect) is considered a potential cause of TdeP; drugs with higher values are labeled as even more likely to be arrhythmogenic. Many antiarrhythmic drugs, psychiatric drugs, anti-infectives, ...
In short, it messes with the electrical functions of the heart. It causes changes in the way the heart beats. It prolongs the QT interval and in high doses or in people with existing heart problems can cause torsades de pointes which is an iabnormal heart rhythm with characteristic ECG pat...
Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways. PLoS ONE 2012, 7, e32476. [CrossRef] [PubMed] 55. Manu, K.A.; Shanmugam, M.K.; Ramachandran, L.; Li, F.; Fong, C.W.; Kumar, A....