Drug metabolism is the process the body uses to transform drugs so that they can be excreted from the body. Many factors affect...
Drug Metabolism Reviews Boukouvala S, Fakis G. Arylamine N-acetyltransferases: what we learn from genes and genomes. Drug Metab Rev. 2005;37:511-64.Boukouvala S, Fakis G. Arylamine N-acetyltransferases: what we learn from genes and genomes. Drug Metab Rev. 2005;37:511-64....
and acetylation, respectively. One common cause of dangerous drug interactions is when one drug has an effect on the patient's metabolism that interferes with the body's ability to metabolize another drug, allowing the latter to accumulate unprocessed until it reaches dangerous levels and poisons th...
Para-methoxybenzaldehyde is not only an important intermediate for organic preparation, but also a raw material for the preparation of drugs and cosmetics. Use it as an intermediate to produce antimicrobial drug amoxicillin and prepare porphyrin photosensitizer. The pmethoxybenzaldehyde produced by Japan's...
Isothermal Microcalorimetry (IMC) is a highly sensitive analytical technique that measures the heat flow in chemical and physical processes under constant temperature. IMC enables the precise detection of thermal reactions, including phase transitions, binding events, and metabolic processes, making it inva...
Wegovy is also approved for chronic weight management in pediatric patients aged 12 years and older. In studies, a 16.1% decrease in body mass index (BMI) in children 12 years of age and older was demonstrated. Approval for Wegovy in children was supported by the 68-week Phase 3a STEP ...
This interference inhibits cellular growth, interrupting its transition from phase G1 to phase S. Ultimately, the action on mTORC1 is responsible for the beneficial effects of the drug on cellular proliferation. However, although sirolimus cannot directly inhibit mTORC2, it was shown that its ...
Abstract Antibody secretion is executed by plasma cells that are generated in the periphery and migrate to the bone marrow to establish a long lived pool. The terminal differentiation of B lymphocytes into plasma cells is executed by a network of transcription factors that cross-regulate each other...
Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: Integrated analysis of three phase 1–2 trials. Lancet Oncol. 2020, 21, 271–282. [Google Scholar] [CrossRef] Drilon, A. TRK inhibitors in TRK fusion-positive cancers. Ann. Oncol. 2019, 30, 23–30...
IL-6 is yet another cytokine produced during inflammation that has a large influence. IL-6 functions as a lymphocyte growth and differentiation factor and induces the release of acute-phase proteins in the liver. Even though IL-6 does not seem to be a direct mediator of tissue injury, chroni...