65 Phase II drug metabolism UGT1A enzyme affects cellular response of colon cancer cells to antitumor triazoloacridinone C-1305 treatmentHonors thesis project submitted in partial fulfillment of the requirements for Honors Program.doi:10.1016/S0959-8049(14)70191-1Augustin, E....
phase II drug metabolismSARArylamine N-acetyltransferases (NATs) are a family of phase II drug-metabolising enzymes which are important in the ... Westwood,M I.,Kawamura,... - 《Current Topics in Medicinal Chemistry》 被引量: 48发表: 2006年 Pharmacogenetics of the antiepileptic drugs phenytoin...
“Phase I and Phase II” Drug Metabolism: Terminology that we Should Phase Out?: Drug Metabolism Reviews: Vol 37, No 4 Click to increase image sizeClick to decrease image size PD Josephy,FP Guengerich - 《Drug Metabolism Reviews》 被引量: 64发表: 2005年 Pharmacokinetics of traditional ...
Sulfotransferases (STs) are important phase II drug-metabolizing enzymes. STs are involved in the sulfation processes of some TAM metabolites (i.e., ... S Maiti,G Chen - 《Drug Metabolism & Disposition the Biological Fate of Chemicals》 被引量: 71发表: 2003年 A possible modulatory influence...
2) Drug metabolites 药物代谢产物 3) phase II metabolite II相代谢产物 1. AIM To study thephase II metabolites of phenoprolamine hydrochloride (DDPH) in rat bile. 目的 研究大鼠服药后胆汁中盐酸非洛普 (DDPH)II相代谢产物。 4) pharmacokinetics[英][,fɑ:məkəu,kai'netiks] [美][,fɑrm...
Part 3: pharmacogenetic variability in phase II anticancer drug metabolism. Oncologist 2011;16:992-1005. http://dx.doi.org/10.1634/theoncologist.2010-0260.Deenen MJ, Cats A, Beijnen JH, Schellens JH. Part 3: pharmacogenetic variability in phase II anticancer drug metabolism. Oncologist. 2011...
The role of drug metabolism in drug discovery (lead compound selection) and the traditional role of identifying the enzymes involved in biotransformation pathways (reaction phenotyping) have both relied heavily on the availability and use of a human liver bank. The assessment of drug metabolizing enzy...
Many of these phytochemicals are known to cause the induction of the Phase II drug metabolizing enzymes such as Glutathione S-transferase (GST) and NAD(P)H: quinone oxidoreductase (QR). The induction of the phase II enzymes is b...
In an attempt to better appreciate the relevance of a widely used mouse colon tumor (colon adenocarcinoma Co38) as a screening model for human colorectal tumors, we compared the main phase I and phase II drug-metabolizing enzyme systems in both tumoral and nontumoral colon tissues. The ...
For these reasons CA-4 is one of the most potent anti-vascular agents that shows strong cytotoxicity against a variety of human cancer cells, including multi-drug-resistant cancer cell lines. In order to complete the knowledge of metabolic fate of CA-4, the in vitro and in vivo phase II ...