Un-coupling of CMs ↑ PCNA N.A. Wang, J. et al. [23]* Reactivation of embryonic cardiac sarcomeric proteins in the cells between infarct zones and intact myocardium ↑ MCM5 (G1/S marker)↑ pH 3 ↑ N2.261 antigen (identified by antibody screening, named as embCMHC) Sallin, P. et ...
If further LDL-C reduction is needed despite maximally tolerated statin therapy, all 3 guidelines recommend the additional use of ezetimibe as the practical next step, reserving PCSK9 monoclonal antibody inhibitors as the third step (Table 1). CCS 2021 and ESC/EAS 2019 also recommend the addition...
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This is caused by replication-coupled proliferating cell nuclear antigen (PCNA) and CRL4Cdt2-dependent degradation of p21 (Abbas et al., 2008, Havens and Walter, 2011, You et al., 2002) and is required for the proper execution of S phase. In cancer cells, artificially elevating p21 ...