An enzyme is a protein that acts as a biocatalyst that mediates the biological reaction. All the type of metabolic reactions that are taking place in the human body require the help of enzymes. It regulates the rate of biological reaction and does not get involved in the particular reaction....
However, support for the indirect promotion of the immunogenicity of CYP proteins through their adduction has been provided through the identification of antibodies directed against the native enzyme. A classic example of which is observed with tienilic acid, with this drug formation of a thiophene ...
enzyme kineticssimulationsubstrate inhibitionA common variant of the Michaelis-Menten model of enzyme kinetics involves inhibition by excess substrate. This phenomenon is known as substrate inhibition and the mathematical description of it requires an inhibition constant (Ki) as well as the usual kinetic...
Some questions on enzyme kinetics : - What does Km says and what does a high/low value mean ? - What does kI says and what does a high / low mean? what should it be to be a good inhibitor? - What does Kcat says about trypsine /enzyme activity in a reactio Describe the mechanis...
What are the effects of drugs on Treg cells in multiple myeloma, and what are the applications of treg cells in therapy? Introduction Multiple myeloma (MM) is the most common form of plasma cell malignancy, accounting for about 1.7% of all malignant tumors [1]. Although the use of a vari...
Imaging dopamine transmission in schizophrenia: a review and meta-analysis. Q J Nucl Med. 1998;42(3):211-2219796369PubMedGoogle Scholar 21. Smith Y, Kieval JZ. Anatomy of the dopamine system in the basal ganglia. Trends Neurosci. 2000;23(10):(suppl) S28-S3311052217PubMedGoogle Scholar...
Yet more progress was made by Jedrzejewski et al. [97], who used a dynamic model for cell death and growth together with the dynamic model from del Val [93] to predict glycosylation patterns. In this case, experimental data from mAb producing mouse hybridoma cells was used for the ...
Fixed the rule for the initial value for the parameter Ki of Morrison equation in enzyme inhibition. Improved wording of message if you tried to perform the One-way ANOVA analysis with data entered as mean & SD (or SEM), without N (which is essential), or if each column had only one ...
Explain the expected variation of optimal temperature ranges for enzyme activity in endotherms and ectotherms. Some questions on enzyme kinetics : - What does Km says and what does a high/low value mean ? - What does kI says and what does a ...
What value of (s), as a fraction of km, is required to obtain 20% vmax? (s) equals: Michaelis-Menten Kinetics: Michaelis-Menten kinetics describe enzyme activity under specific conditions. The concentration of the enzyme is held constant while the concentration of the su...