Time dependent inhibition of cytochrome P450 (CYP450) enzymes: Time dependent inhibition of cytochrome P450, often caused by an irreversible or quasi-irreversible interaction, can lead to clinically relevant drug-drug interactions or non-linear pharmacokinetics of a drug. In addition, these interactions...
equation; (2) the rate of the reaction depends on the amount of the enzyme-substrate complex; (3) a rapid equilibrium steady state method is used;4 and (4) only reversible inhibitors are discussed. Reactions involving one substrate vlnax s ...
There were no clinically significant differences in the pharmacokinetics of mirikizumab-mrkz based on age (18 to 79 years), sex, race (White or Asian), or mild and moderate renal impairment (i.e., estimated creatinine clearance by Cockcroft-Gault equation: 30 to 89 mL/min). Body Weight...
Ki和IC50的关系
Kinesin-13s are critical microtubule regulators which induce microtubule disassembly in an ATP dependent manner. To clarify their mechanism, we report here the crystal structure of a functional construct of the kinesin-13 Kif2C/MCAK in an ATP-like state
a) Explain and use the terms: rate of reaction; activation energy; catalysis; rate equation; order of reaction; rate constant; half-life of a reaction; ratedetermining step. b) Explain qualitatively, in terms of collisions, the effect of concentration changes on the rate of a reaction. c)...
Drugs or vehicle were administered for a period of 21 days, beginning on the day one week after the tumors became palpable. 3.3. Measurement of Tumor Volume The tumor dimensions were measured twice a week using a linear caliper, and tumor volume was calculated using the equation v (mm3) =...