Isotype refers to the class of an antibody determined by its constant region. Idiotype refers to the unique antigen-binding site of an antibody, determined by its variable region.
For example, in immunology flow cytometry is used to identify, separate, and characterize various immune cell subtypes by virtue of their size and morphology. When additional information is required, antibodies tagged with fluorescent dyes, and raised against highly specific cell surface antigens (e....
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A new study by Honjo and colleagues, recently published in Science , adds to the controversy about the role of activation-induced cytidine deaminase ( AID ) in class-switch recombination (CSR) — the process by which antibodies switch their isotype from IgM to IgG, IgA or IgE by ...
In the germinal center early stage antibody-secreting B cells undergo isotype switching and transition into a plasma cell. Antibody production by B cells can quickly neutralize a potential infection. Once the infection is neutralized, B cells can become memory B cells, which exist in small numbers...
Analysis of immunoglobulin E VH transcripts in a bronchial biopsy of an asthmatic patient confirms bias towards VH5, and indicates local clonal expansion, somatic mutation and isotype switch events. Immunology. 1999;98(4):646–51. Article PubMed CAS Google Scholar Takhar P, Corrigan CJ, ...
Further research is required on the role of ‘non-criteria’ aPL, including anti-phosphatidylserine/prothrombin (aPS/PT), anti-β2-glycoprotein I domains 4/5 [48], and, due to their role in mucosal immunology, both anticardiolipin and anti-β2-glycoprotein I antibodies of the IgA isotype [...