The purine nucleoside Ribavirin inhibits (among other potential modes of action) the inosine monophosphate dehydrogenase (IMPDH) protein and induces a reduction in the GTP pool, a mechanism that has been shown to correlate with its antiviral activity against several RNA viruses [339]. Ribavirin has...
Twitter Google Share on Facebook AcronymDefinition IMPDIndianapolis Metropolitan Police Department(Indianapolis, Indiana) IMPDInvestigational Medicinal Product Dossier IMPDInosine Monophosphate Dehydrogenase IMPDInstitute for Multi-Party Democracy IMPDInstitute of Malaria and Parasitic Diseases(Kabul, Afghanistan) ...
Synthesis, Structure, Antitumor Activity, and Interactions with Inosine Monophosphate Dehydrogenase. J. Med. Chem. 1995, 38, 3829–3837. [Google Scholar] [CrossRef] Kabat, M.M.; Pankiewicz, K.W.; Watanabe, K.A. Nucleosides. 141. Synthesis of 5-β-D-Ribofuranosylnicotinamide and Its N-...
The phenolic glucuronide of mycophenolic acid, (MPAG), the primary metabolite of MPA, is produced by UDP-glucuronosyltransferase(s) in liver and possibly other tissues such as kidney and small intestine. The apparent inhibition of inosine monophosphate dehydrogenase by mycophenolic acid glucuronide is...
we have to consider that the current standard therapy for hepatitis C may be associated with severe side effects and is associated with significant costs, making only a minority of patients eligible for treatment.[6]Thus, what can the clinician tell his patients if they ask about new drugs in...
In addition, neither phosphocreatine (PCr) content nor the total adenine nucleotide pool (TAN = ATP + ADP + AMP), nor the degradation products inosine 5′-monophosphate (IMP) nor hypoxanthine were different from pre-exercise resting values. Figure 13. Muscle glycogen concentrations (panel A) ...
(3) Nonstandard abbreviations: MPA, mycophenolic acid; IMP-DH, inosine 5'-monophosphate dehydrogenase; XMP, xanthosine 5'-monophosphate; MMF, mycophenolate mofetil; MPAG, MPA glucuronide; HSA, human serum albumin; FBS, fetal bovine serum; DPBS, Dulbecco s PBS; and HBSS, Hanks' balanced salt ...
(HPRT) [18], which acts to salvage purines from degraded DNA, taking intracellular hypoxanthine to inosine monophosphate (IMP) and xanthine to xanthine Monophosphate (certain isozymes), and a deficiency or absence of this enzyme results in elevated concentrations of XOR substrates in the cell [19...
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