Treatment of HER2-positive breast cancer The human epidermal growth factor receptor 2 gene (HER2) is overexpressed and/or amplified in 鈭 15% of breast cancer patients and was identified a quarter ... MC Figueroa-Magalhães,D Jelovac,RM Connolly,... - 《Breast》 被引量: 141发表: 2014年...
However, despite the tremendous progress attained, disease progression, even with trastuzumab and lapatinib treatment, is inevitable in metastatic breast cancer. Thus, research efforts have focused on finding alternative therapies to trastuzumab and lapatinib for the treatment of Her2-positive breast cancer...
What is triple negative breast cancer? Triple negative breast cancer (TNBC) means that the cancer cells do not have estrogen (ER) and progesterone (PR) on their surface, and they do not over-express the HER2 protein as well (HER2−). In contrast to TNBC, triple positive breast cancer ...
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To summarize the treatment strategies for patients with human epidermal growth factor receptor 2 (HER2)-positive disease and triple-negative breast cancer (TNBC) who have residual disease after preoperative systemic therapy.#There has been a shift towards neoadjuvant systemic therapy for selected patients...
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What is breast cancer?Breast cancer develops when cells in the breast grow out of control. Several types of breast cancer can develop, depending on which cells turn into cancer. Most breast cancers start in the tissue or ducts of the breast.What increases my risk for breast cancer?
Joshua K. Sabari, MD; Jamie Chaft, MD; and Vamsidhar Velcheti, MD, recap the 2021 ASCO Annual Meeting and focus on data presented in patients with non–small cell lung cancer that is HER2 positive or harbors an exon 19 deletion.Related...
Trastuzumab is indicated for: HER2-positive metastatic breast cancer Early-stage breast cancer HER2-positive early-stage breast cancer Adjuvant therapy in combination with docetaxel and carboplatin Neoadjuvant therapy followed by adjuvant therapy for locally advanced (including inflammatory) or tumor size >...
Kadcyla is another cancer medicine that is also used to treat HER2-positive metastatic breast cancer. It is usually given after other cancer medications have been tried without success. Both Enhertu and Kadcyla are classified asHER2 inhibitors. ...