Potential strategies for improving the outcomes of patients with early stage HER2-positive (HER2+) breast cancer have included dual anti-HER2 therapy. Recent results from the APHINITY trial show a statistically significant, but clinically modest, benefit from the addition of pertuzumab to trastuzumab ...
Treatment of HER2-positive breast cancer The human epidermal growth factor receptor 2 gene (HER2) is overexpressed and/or amplified in 鈭 15% of breast cancer patients and was identified a quarter ... MC Figueroa-Magalhães,D Jelovac,RM Connolly,... - 《Breast》 被引量: 141发表: 2014年...
Breast cancer is a disease that starts in the breast with a malignant tumor. A malignant tumor is a mass of cells that grows out of control. The cancerous cells can also metastasize, or move to other tissues or parts of the body. The cancer can develop in any of the three types of ...
What is the survival rate of stage 4 lung cancer? What is the survival rate for stage 1 lung cancer? What are the survival rates of ovarian cancer? What is medullary thyroid cancer? What is the survival rate of HER2 positive breast cancer?
Triple negative breast cancer (TNBC) means that the cancer cells do not have estrogen (ER) and progesterone (PR) on their surface, and they do not over-express the HER2 protein as well (HER2−). In contrast to TNBC, triple positive breast cancer means the cancer cells are ER+, PR+,...
Mutations and amplification of the HER2 gene can lead to excessive presence (overexpression) of HER2 proteins on the cell surface, a major cause forbreast cancer. Cancers caused by HER oncogenes include: HER2 positive breast cancer Non-small-cell lung carcinoma ...
How is Enhertu used in metastatic breast cancer? Enhertu (fam-trastuzumab deruxtecan) is approved to treat adults with human epidermal growth factor receptor 2 (HER2)-positivebreast cancerthat cannot be removed by surgery (unresectable) or that has spread to other parts of the body (metastati...
To summarize the treatment strategies for patients with human epidermal growth factor receptor 2 (HER2)-positive disease and triple-negative breast cancer (TNBC) who have residual disease after preoperative systemic therapy.#There has been a shift towards neoadjuvant systemic therapy for selected patients...
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937 Words 4 Pages Open Document Breast cancer is one of the most common cancers and the second leading cause of cancer-related death among women in the United States. Up to 6% of breast cancers are advanced or metastatic at the time of diagnosis, requiring chemotherapy1, 2. Aberrant, accele...