vivo gene therapy to be expressed in the tissue, they must be inserted into cells that are undergoing mitosis, the process of cell division. This allows the new DNA to spread through the patient’s tissues. After the virus delivers the new DNA, it dies or is attacked by theimmune system...
Gene therapy is becoming an important part of cellular therapy for cancer and hematologic malignancies, particularly, dendritic cell (DC) therapy. DCs have been used in many clinical trials of immun...Berg M, Childs R. Ex-vivo expansion of NK cells: what is the priority - high yield or ...
Stem cell therapy has been developing for the last 40 years, and it has shown results in the treatment of different diseases, from neurological to heart and autoimmune pathologies. At the same time, in the news or on the internet, cell therapy is often promoted with alerts that it has adve...
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder that is characterized by abdominal pain and an altered defecation pattern. It affects between 5 and 20% of the general population and can seriously impact quality of life. The pathophysiology of IBS is rather complex an...
CRISPR. What is it? And why is the scientific community so fascinated by the potential applications of this gene-editing technology? Starting with its definition, we explain how this technology harnesses an ancient bacteria-based defense system — and how it will impact the world around us today...
AsFDA Commissioner Scott Gottlieb notedin his announcement of the new gene therapy guidances, some of the more challenging issues for gene therapy product development relate to product manufacturing and quality. The new CMC-focused draft guidance is intended to explain how FDA approaches...
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Animal models of retinal ischemia A number of in vivo and ex vivo animal models have been developed to study retinal ischemia. In order to best extrapo- late the data from animal model to human clinical situation, the model which most closely resembles human retinal isch- emia is preferred....
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despit......
Although some viruses, such as EBV and cytomegalovirus (CMV), produce an IL-10- like molecule that functions in vitro in a similar manner to host IL-10, it is still not clear if this viral IL-10 has any role during viral infections in vivo24,25. Host-derived IL-10 can block pro-...