In lupus model mice, anti-nucleosome antibodies are reported to emerge even before the production of anti-dsDNA antibodies. BK virus T antigen, bacterial DNA, a DNA binding protein nucleobindin and autoreactive helper T cells specific to nucleosome or anti-DNA antibody-derived peptides have been...
该23岁女性患者具有6年难治性SLE病史,临床表现为活动性狼疮性肾炎、溶贫、多形性皮疹和多关节炎。经过双抗治疗,患者外周血B细胞迅速耗竭,抗dsDNA抗体转阴,且黏膜皮肤和肌肉骨骼症状实现了快速且不依赖药物的完全缓解,为难治性SLE患者开辟了新的治疗...
Other first-line tests for differential diagnosis include dsDNA, IgG; Smith/RNP, IgG; Smith (ENA), IgG; SSA 52 and 60, IgG; SSB, IgG; Jo-1, IgG; Scl-70, IgG.16(The Choosing Wisely Campaign recommends not ordering ANA subserologies if the ANA is not positive.)17 ...
T7 噬菌体是一种典型的短尾裂解性噬菌体,由内径为55nm的二十面体头部(直径约为60nm)和19nm的尾部(含6根尾丝)组成外壳蛋白,包裹一条长为40kbp的线性dsDNA基因组(含55个基因)。T7噬菌体的宿主菌为表面粗糙的大肠杆菌,前者通过尾丝蛋白识别吸附到后者的受体上,然后通...
STING is a vital protein in the innate immune response. Learn how Bio-Techne's STING Antibodies can be used in your cancer and immunology research.
They are called nucleoids. Unlike eukaryotic nuclei, they are not enclosed in the nuclear membrane and lack nucleolus and nucleoplasm. It is represented by a dsDNA molecule either in a closed circular form or in coiled form. Bacterial DNAs are found either in nucleoid as chromosomal DNA or ou...
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In bacteria, they are heterotetramers (A2B2), whereas in eukaryotes, they are homodimers (A2), where each half of the enzyme is fused into a single subunit (denoted with a dashed line). The type IA enzymes act on a larger variety of substrates, such as ssDNA, nicked DNA, dsDNA, ...
Twitter Google Share on Facebook AcronymDefinition cANCACytoplasmic Antineutrophil Cytoplasmic Antibody(pathology) cANCACombined Aboriginal Nations of Central Australia cANCAClassic AntiNeutrophil Cytoplasmic Antibody cANCACirculating Anti-Neutrophil Cytoplasmic Antibody ...
porto-sinusoidal vascular disorder, PSVD, obliterative portal venopathy, non-cirrhotic portal hypertension, rheumatology, systemic autoimmune disease, systemic lupus erythematosus, antiphospholipid antibody, Sjogren's, systemic sclerosis, inflammatory myositis, vasculitis, rheumatoid arthritis, Felty's syndrome....