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et al. Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J. 28, 2414–2427 (2009). Lamin A has a role in the compartmentalization of telomeres in the nucleus, and loss of lamin A results in telomere shortening and affects the epigenetic status ...
Malaria has inflicted serious morbidity and mortality across the globe. The major brunt of the disease has been on African, South-East Asian and South American countries. Proportionally, malaria has attracted global research priorities and this is eviden
Autism spectrum disorder (ASD) is a group of complex developmental disorders clinically characterized by behavioral symptoms, such as impaired communication skills, defective social interaction, and the presence of repetitive behaviors [19]. ASD significantly limits the individual’s capacity to live indep...
PCR is a Polymerase Chain Reaction. Kary Mullis developed it in 1983. It is a technique used to amplify a specific segment of DNA. The technique mainly involves three steps: denaturation, annealing, and elongation. This technique is commonly used in molecular biolo...
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling Nature, 444 (7120) (2006), pp. 724-729 CrossrefView in ScopusGoogle Scholar [4] J.N. Mandl, J.P. Monteiro, N. Vrisekoop, R.N. Germain T cell-positive selection uses self-ligand binding strength to optimize...
Cajal’s observations provided critical support for the neuron doctrine, which postulates that the neuron is the central unit of the brain. At the same time, his drawings revealed the beautiful complexity, polarity, and compartmentalization of neurons: cell bodies elaborating axonal and dendritic ...
The example of daclizumab illustrates quite well that there is no guarantee that a therapy which has been proven to be effective and safe for use in one condition, will work with the same safety profile in another condition. Daclizumab was initially developed as an intravenous therapy (Zenapax...
The end of mankind is,to put it bluntly, actually a severing and compartmentalization of the before and after of man, not regeneration, but super-birth, but Mang birth. After that is the cut off of the previous, only before the cut off, after the doomsday can be a new Mang-start......
The tsetse and weevil endosymbionts discussed in this review have retained some genes that are known in other systems to be required for host cell infection, which is the first step of the compartmentalization process. These genes include those that encode type III secretion systems in S. ...