In thereportfrom the University of Washington Medical Center, the researchers reviewed over 600 patient files who had had NIPS testing. Their research showed that while cfDNA testing, also referred to as Non-Invasive Prenatal Screening (NIPS), can be a reliable screen when used as a second...
This testing analyzes small fragments of DNA that are circulating in a pregnant woman’s blood, which was called cell-free DNA (cfDNA). NIPT is considered noninvasive because it only requires drawing blood from the pregnant woman to test whether a fetus has a genetic condition and does not ...
Preeclampsia is a hypertensive disorder in pregnancy characterized by placental malperfusion and subsequent multi-organ injury. It accounts for approximately 14% of maternal deaths and 10–25% of perinatal deaths globally. In addition, preeclampsia has b
I began this post by saying “Again” it was reported that NIPS was inferior to traditional screening. That “again” is because at the previous year’s SMFM conference in 2014it was reported by several studiesthat NIPS failed to identify as many conditions as other variations of prenatal tes...
of NIPT false positives, where the fetuses are later found to be healthy.3This is why the American College of Obstetricians and Gynecologists (ACOG) guidelines reiterate that cfDNA has the potential for false positive and false negative results and is not the equivalent of diagnostic testing.4 ...
Ovarian cancer is the most lethal gynaecological malignancy. Despite the introduction of bevacizumab, standard chemotherapy has remained largely unchanged
Furthermore, the sFlt-1/PlGF ratio test is likely to lessen the avoidable hospitalization of women at low risk of developing PE in the short term while identi- fying high-risk individuals requiring appropriate manage- ment [14]. Besides sFlt-1 and PlGF, several biomarkers have been reported ...
However, if the amount of RNA extracted from tissues or cells is low or if, due to the formalin fixative, RNA is degraded, the RNA NGS approach has it limits. Moreover, depending on the type of NGS sequencing technique, the detection of fusion partners concerns only those known and ...
with the age of the mother, even a 45-year-old mom’s chance of having a child with Down syndrome is 1-in-35. The other testing companies have also reported their accuracy levels in populations already designated as “high-risk,” usually women 35 and older or those who alr...
with the age of the mother, even a 45-year-old mom’s chance of having a child with Down syndrome is 1-in-35. The other testing companies have also reported their accuracy levels in populations already designated as “high-risk,” usually women 35 and older or those who already h...