Areas covered This review provides an overview of the more than 20 drug classes in clinical development for T2D, with an outline of their mode of action, efficacy, safety, and current status. Expert opinion New GLP-1 RA and SGLT-2i are dominating the clinical pipeline. A range of gluco...
The failing heart is energy deficient, has diminished glucose, and depends on fatty acid oxidation [8]. Free fatty acids contribute to arrhythmias. Drug therapy, particularly angiotensin receptor-neprilysin inhibitor (ARNI) – sacubitirl/valsartan and sodium-glucose cotransporter-2 inhibitor (SGLT2i)...
SARS-CoV-2 sites of infection and complications in diabetic patients. As is the case for SARS-CoV, SARS-CoV-2 uses the ectopeptidase ACE2 as an entry site in human host cells. ACE2 is part of the renin-angiotensin system, responsible for the termination of the angiotensin signal, promotin...
As an antidiabetic agent, SGLT-2 inhibitors improve plasma glucose levels by increasing renal glucose and sodium excretion and lowering intraglomerular pressure [46,47,48]. SGLT-2 inhibitors exert a wide range of pleiotropic actions, some of which may prove as important future targets of therapy....
Dapagliflozin, developed jointly by Bristol-Myers Squibb and AstraZeneca, is a novel anti-diabetic drug. It belongs to the class of SGLT2 inhibitors, which are used as an important option in the treatment of type 2 diabetes. Dapagliflozin works by inhibiting sodium-glucose cotransporter 2, a pr...
is unique to a given patient's tumor. The idiotype protein is then linked to an immunogenic protein called keyhole limpet hemocyanin (KLH) and administered with GM-CSF to enhance the immune response. Upon administration, the body recognizes KLH as a foreign substance, and it mounts an immune ...
However, at the drug level, spending increased over the same time period and thus resulted in projected negative impacts to patient outcomes. The second and third hypothetical budget cap growth strategies, which included inflation adjustment using the CPI-U in combination with an adjustment for ...
“Well, testosterone is a regulated substance and you can’t necessarily give the patient an unlimited supply. We have to think about how we distribute the drug to them. Another of the trials involves an injectable agent, and for the first few visits the patient was going to be injecting ...
However, the transport of urate in the proximal tubule is bidirectional: reabsorption and secretion. Thus, an increase in reabsorption or a decrease in secretion may induce hyperuricemia. In contrast, a decrease in reabsorption or an increase in secretion may result in hyper...
The obesity treatment market is being revolutionized. The global sensation is the GLP-1 drug Wegovy (semaglutide), which has been shown to improve cardiovascular and metabolic diseases beyond just weight loss.Wegovy has set a new standard for obesity tre