Work in recent decades illustrated the vital role of metabolic deregulation in tumor cell survival and resistance to cytotoxic therapy7,8. In normal prostatic tissue, androgen receptor (AR) signaling guides the utilization of glucose and amino acids through glycolysis and the tricarboxylic acid (TCA)...
METHODS FOR TREATING TYPE 2 DIABETES IN PATIENTS RESISTANT TO PREVIOUS TREATMENT WITH OTHER ANTI-DIABETIC DRUGS EMPLOYING SGLT2 INHIBITOR AND COMPOSITIONS THEREOFPROBLEM TO BE SOLVED: To provide methods for treating a patient having type 2 diabetes who has failed on previous regimens of one or more...
PAUL STRUMPHポールストランプSTEPHANIE MORANステファニーモランJAMES LISTジェイムズリスト
It is also necessary to evaluate and exclude the presence of secondary causes of liver steatosis, such as drugs, hereditary metabolic disorders, and other chronic liver diseases [3]. Due to the recent spread of obesity and metabolic syndrome (MetS), NAFLD is now considered to be the chronic ...
Although many kinds of oral antihyperglycemic agents with different therapeutic mechanisms have been marketed, their undesirable adverse effects, such as hypoglycemia, weight gain, and hepato-renal toxicity, have increased demand for the discovery of novel, safer antidiabetic drugs. Since the important ...
The Era of Targeted Therapies in Cardiology 2.0Advances in Pharmacogenetics Research of Chemotherapeutic Drugs for Acute LeukemiaAdvances in PharmacomicrobiomicsAdvances in Tumor Microenvironment and Drug DeliveryAdvances on Nanomaterials Derived from Natural Resources and Their Biomedical ApplicationsAlcohol and Op...
A list of published CVOTs with SGLT2 inhibitors is shown in Table 3. Table 2. Effects on CVD risk among glucose-lowering agents. Table 3. Cardiovascular outcome trials (CVOTs) with SGLT2 inhibitors. 5. Adverse Effects The adverse effects of SGLT2 inhibitors other than hypoglycemia include...
combination therapy may be required because of the limited efficacy of single-target drugs; however, medications are becoming more costly, and there is also the risk of developing the combined side effects of each drug. Thus, identifying a multi-target drug may be the best strategy to improve ...