Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation Establishment of oligodendrocyte identity is crucial for subsequent events of myelination in the CNS. Here, we demonstrate that activation of ATP-dependent... Y Yu,Y Chen,B Kim,... - 《Cell》 被引量: 252...
Oligodendrocyte pathology is evident in a range of disorders including multiple sclerosis, schizophrenia, and Alzheimer’s disease (Kuhn et al., 2019). Regarding cerebrovascular cell types, recent single-cell transcriptomic studies in the human brain reveal gene expression changes in them that can ...
Watson RA, Yeung TM (2011) What is the potential of oligoden- drocyte progenitor cells to successfully treat human spinal cord injury? BMC Neurol 11:113Watson RA,Yeung TM.What is the potential of oligodendrocyte progenitor cells to successfully treat human spinal cord injury?[J].BMC Neurol,...
BBB breakdown in neurodegenerative disease is likely important for GMB and peripheral involvement in disease progression. After BBB breakdown, peripheral immune cells, cytokines, and metabolites can more easily enter the brain and have an effect on brain resident cells and neuropathological progression ...
An ___ forms myelin sheaths around the axons of several central nervous system neurons. What protects the axon on the neuron, and what is it made out of? Define the following: dendrite, oligodendrocyte, axon, the myelin sheath. What is the part of a neuron that carries nerve...
Which type of glial cell is most likely involved with creating the white matter in the corpus callosum? A. Schwann cell B. Microglia C. Oligodendrocyte D. Astrocyte What are ciliated CNS neuroglia that play an active role in moving the cerebrospinal fluid called? a) oligodendrocytes b) Schwann...
[42]. Induction of this astrocyte subtype could be therapeutic for several neurological diseases. Similar therapeutic strategies could be applied to GMB-regulated microglial, neuronal, and oligodendrocyte subtypes/substates. Additionally, manipulation of GMB-regulated peripheral inflammatory subtypes/substates ...
As NMOSD can be suspected through clinical examination, MRI is used to help differentiate NMOSD from other CNS inflammatory demyelinating disorders such as MS and myelin oligodendrocyte glycoprotein (MOG) Ab disease.5 In patients with NMOSD, MRI typically reveals lesions in AQP4-rich area...
Oligodendrocyte D. Astrocyte Which of these cell types does not regenerate? a) smooth muscle. b) nerve cells. c) adipose tissue. d) dense irregular connective tissue. Which of the following is a type of glial cell found in the peripheral nervous...
Myelin oligodendrocyte specific protein EAE: Experimental allergic encephalomyelitis MS: Acknowledgments The authors thank our fellow collaborators in the Aging Program Project (NIA AG00001) particularly Drs. Peters, Rosene, Moss, Leubke, Hollander, Duce, and Chen. ...