Multiple sclerosis genetics--is the glass half full, or half empty? Multiple sclerosis (MS) is a common and severe CNS disorder that is characterized by myelin loss, chronic inflammation, axonal and oligodendrocyte patholog... JR Oksenberg,SE Baranzini - 《Nature Reviews Neurology》 被引量: 181...
Oligodendrocyte pathology is evident in a range of disorders including multiple sclerosis, schizophrenia, and Alzheimer’s disease (Kuhn et al., 2019). Regarding cerebrovascular cell types, recent single-cell transcriptomic studies in the human brain reveal gene expression changes in them that can ...
and lots of repeat signals from a particular axon triggers the astrocyte to release chemicals that stimulate the second cell (known as an oligodendrocyte) to produce
“Another exciting aspect is our growing understanding of the mechanisms of autoimmunity in patients with epilepsies having an autoimmune cause. A lot of work, particularly from Europe, focuses on neuropathological findings in patients with autoimmune-associated epilepsies. We are starting to understand...
[42]. Induction of this astrocyte subtype could be therapeutic for several neurological diseases. Similar therapeutic strategies could be applied to GMB-regulated microglial, neuronal, and oligodendrocyte subtypes/substates. Additionally, manipulation of GMB-regulated peripheral inflammatory subtypes/substates ...
[42]. Induction of this astrocyte subtype could be therapeutic for several neurological diseases. Similar therapeutic strategies could be applied to GMB-regulated microglial, neuronal, and oligodendrocyte subtypes/substates. Additionally, manipulation of GMB-regulated peripheral inflammatory subtypes/substates ...
However, in multiple sclerosis, the differentiation of oligodendrocyte lineage cells pr... Kotter,R M. - 《Journal of Neuroscience the Official Journal of the Society for Neuroscience》 被引量: 677发表: 2006年 What is the patient's perspective: How important are patient-reported outcomes, ...
Autoimmune encephalitis is a relatively novel nosological entity characterized by an immune-mediated damage of the central nervous system. While originally
Imaging mass spectrometry (IMS) makes it possible to see the spatial distribution of molecules in a thin tissue section based on their molecular masses. It is a powerful tool for biomarker discovery, but identifying proteins detected by IMS remains a difficult task. ...
The authors also claim that p62 protein, known to recognize toxic cellular waste to be processed by autophagy, is accumulated in the brain of nclf mice, but there is an issue with the amount of protein loaded and it is difficult to ascertain differences between nclf and wild type mice [...