An understanding of the development and function of oligodendrocytes is a central issue in assessing the contribution of these cells to the pathology of multiple sclerosis. In particular, repair processes, especially those which relate to neuron-glia and possibly also to astrocyte- oligodendrocyte ...
we observed an ablation of 70–85% of dorsally derived oligodendrocyte lineage cells (dOLCs) in the cerebral cortex (Fig.1b,e), corpus callosum (CC) (Extended Data
Describe the function of: a. an astrocyte b. an ependymal cell c. oligodendrocyte d. microglia e. neurolemmocyte Describe the canaliculi and give its function. Describe the various functions of secretin. Describe the functions of the pupil. ...
The importance of the oligodendrocyte lineage and the myelin in the healthy brain OLGs are a major glial cell type in the CNS, which con- stitute around 75% of the CNS glial cell population [80]. OLGs are responsible for the production, stability, and maintenance of myelin ...
"Oligodendrocyte" means "cellwith a few dendrites" in Greek, an appellation that stems from their relatively delicate appearance compared to astrocytes, which appear as they do thanks to the robust number of processes radiating in all directions from the cell body. They are found in both the gr...
down-regulated gene categories (Extended Data Fig.3a–d). Ingenuity Pathway Analysis (IPA, Qiagen) identified white matter (WM)-associated pathways in the top categories of altered genes in both sexes (Extended Data Fig.3e,f). Comparison of cerebellar DEGs to previous published oligodendrocyte (...
Fig. 1. Oligodendrocyte and Schwann cell myelination (a), (c) Lateral view of a Tg(sox10:megfp);Tg(nbt:dsred) double transgenic embryo at 3 dpf showing (a) oligodendrocytes (arrowheads) myelinating central nervous system (CNS) axons in the spinal cord and (c) Schwann cells (SCs) (ar...
Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V(3 gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V(3’ and T cell receptor VP’ H-2h mice. Eur J Immunol 1996; 26: ...
acta neuropathol commun (2021) 9:137 https://doi.org/10.1186/s40478-021-01237-z RESEARCH Open Access Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates Feng J. Gao1,2*, ...
* Myelin sheath is made up of cells (Schwann cells) wrapping themselves around the axon. In the Central Nervous System, this action is performed by the oligodendrocyte cells.Nerve ending/ Axon terminalThis is the distal part of the axon that comes in contact with other cells. Because this ...