of proliferating OPCs to differentiate into mature oligodendrocytes leads to myelin loss in neurodegenerative disorders.28 Oligodendrocyte precursors are the primary cell type for development of gliomas.29 Thus, OPCs have a fundamental role both in the normal CNS and in a wide spectrum of pathologic...
What special adaptations do the nervous tissue have to function? Define a nerve tract. What is the primary function of the nervous system? What is the function of a neurotransmitter? What is the function of the microglia? What is the main function of the auditory nerve of the ear? What fu...
What are the functions of the pons?Location of Pons:Pons are found in the middle of the brainstem- specifically they are located above the medulla oblongata which are the lowest portion of the brain. They are known to be about 2.5 centimetres long....
This paper examines work that has been done so far to characterize various aspects of cell death in the retinal ischemia model, such as various pathways which are activated, and the role neurotrophic factors, and discusses how these are relevant to the treatment of ischemic damage in both the ...
The brain is a bumpy, complex structure with holes called ventricles, which are filled with cerebrospinal fluid. Explore the functions and production of cerebrospinal fluid and how this fluid plays an important role in protecting the brain from damage. Related...
Melo Additional information is available at the end of the chapter http://dx.doi.org/10.5772/intechopen.69449 Abstract Exosomes have been implicated in a wide range of pathological and nonpathological processes. Research on tumor-derived exosomes uncovered their role on major processes associated with...
Glioblastoma multiforme (GBM) is a primary brain tumor that is very aggressive, resistant to treatment, and characterized by a high degree of anaplasia and proliferation. Routine treatment includes ablative surgery, chemotherapy, and radiotherapy. However, GMB rapidly relapses and develops radioresistance...
Specifically, different elements have been shown to play a role: (1) the mechanism of invasion; (2) the resident brain structures used by the tumour cells to migrate (e.g., intraparenchymal or perivascular routes); (3) the type of tumour cells; (4) the different elements of the TME (...
Moreover, the specific role of each HDAC is directly related to their specific molecular substrates. To our knowledge, more than 50 non-histone proteins have been identified as substrates for HDACs [9]. On the basis of animal tissue expression and serial analysis of gene expression (SAGE) ...
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