What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochem Int 2000;36:175-84.Coulson EJ, Paliga K, Beyreuther K, Masters CL: What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochem Int 2000,...
Beside amyloid formation, there are other types of aggregation available to a misfold-disease-related polypeptide chain in the proteinfree energy landscape. Among them, native-like aggregation is becoming a widely studied topic of research.This aggregation type, simultaneously straightforward and ...
These include: (1) exacerbation of aging, (2) degeneration of anatomical pathways, including the cholinergic and cortico-cortical pathways, (3) an environmental factor such as exposure to aluminium, head injury, or malnutrition, (4) genetic factors including mutations of amyloid precursor protein (...
amyloid-β AAV adeno-associated virus ABCA1 ATP-binding cassette protein A1 AD Alzheimer’s disease ASOs anti-sense oligonucleotides APOC apolipoprotein C gene APOE apolipoprotein E gene apoE apolipoprotein E APP amyloid precursor protein APP
The major component of senile plaques is amyloid-β-peptide (Aβ), a group of 39–43 amino acid peptides derived from the amyloid precursor protein (APP)[11, 12, 16, 17]. The fact that Aβ is detected in both normal and AD brains[16] indicates that Aβ alone may not be ...
Amyloid precursor protein (APP) PS-1 PS-2 All three of these genes cause early-onset Alzheimer's disease, which means symptoms typically start when people are in their early 40s to mid-50s. A second group of genes is called risk genes. Although they can contribute to the development of ...
aAmyloid-β (Aβ) peptides, derived from the amyloid precursor protein, and the microtubule-associated proteintau are key pathogenic factors in Alzheimer’s disease (AD). How exactly they impair cognitive functions is unknown. We assessed the effects of Aβ and tau on axonal transport of mitoc...
摘要: This essay is written in response to the request of the Regional Mission in Bangkok of the World Bank to produce apaper which" would focus on key factors affecting Thai agriculture, identify principal issues and indicate policy changes needed in the sector for the last...
Association of Cardiovascular Factors and Alzheimer's Disease Plasma Amyloid-β Protein in Subjective Memory Complainers A strong link is indicated between cardiovascular disease (CVD) and risk for developing Alzheimer's disease (AD), which may be exacerbated by the major AD ... KA Bates,HR Sohrab...
Cystatin C colocalizes with amyloid‐β and coimmunoprecipitates with amyloid‐β precursor protein in sporadic inclusion‐body myositis ... Generally accepted as a safe haven for the financial institutions, markets, and people, gold come to the fore especially in times of market stress or crise...