Cell surface receptor function of amyloid precursor protein that activates Ser/Thr kinases. Gerontology 1996; 42 (Supl 1): 2-11.Murayama Y,Takeda S,Yonezawa K et al.Cell surface receptor function of amyloid precursor protein that activates Ser/Thr kinases. Journal of Gerontology . 1996...
Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticityHickM.HerrmannU.WeyerS.W.MallmJ.P.ingentaconnectActa NeuropathologicaHick M, Herrmann U, Weyer SW, Mallm JP, Tschape JA, Borgers M, Mercken M, Roth FC, Draguhn A, Slomianka L, Wolfer DP, ...
Physiological processing of the β-amyloid precursor protein (APP) generates amyloid β-protein, which can assemble into oligomers that mediate synaptic failure in Alzheimer's disease. Two decades of research have led to human trials of compounds that chronically target this processing, and yet the ...
Amyloid-β peptide (Aβ) is the most crucial molecule related to the pathological development of AD. Amyloid-β protein precursor (AβPP) is one of AβPP family members with conserved type I transmembrane. The genetic mutations of AβPP and the abnormity of its post-transcription and ...
Proteolytic processing of the amyloid- precursor protein (APP) generates the A amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional significance...
Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal mod... et at.Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy...
In AD pathology, sequential proteolytic cleavage of amyloid precursor protein (APP) releases toxic amyloid β peptides (Aβ)93. MAM were shown to be the major site of the Aβ formation, since APPs and the majority of the γ-secretase localized to the MAM4,139,140, followed by enlarged ER...
Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ss production. J. Neurosci. 30, 15927–15942 (2010). CAS PubMed PubMed Central Google Scholar Suberbielle, E. et al. Physiological brain activity causes DNA ...
- 1994 - S142 - www.sciencedirect.comdoi:10.1016/0197-4580(94)93038-4Myrset, A.H.Phillips, L.Moore, S.A.Dessen, A.ELSEVIERNeurobiology of Aging
TREM2 is a receptor for β-amyloid that mediates microglial function. Neuron 97, 1023–1031 (2018). CAS PubMed PubMed Central Google Scholar Chakrabarty, P. et al. IFN-γ promotes complement expression and attenuates amyloid plaque deposition in amyloid β precursor protein transgenic mice. J...