When an animal is immunized with a protein, different B cells recognize different epitopes, giving rise to multiple B cell populations. If the blood is collected and the antibodies purified from the serum, the resultant product will contain antibodies from all of those B cell clones, hence the...
Prion proteinligandscoppertransmissible spongiform encephalopathyprion functionPrion protein, a misfolded isoform of which is the essential component of the agent of prion diseases, still remains an enigmatic protein whose physiological functions are at best hypothetical. To gain a better insight into its ...
S. A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. Proc. Natl Acad. Sci. USA 104, 4949–4954 (2007). Article CAS PubMed PubMed Central Google Scholar McClintock, D. et al. The mutant form of lamin A ...
The exceptional complexity of this protein is determined by the presence, in humans, of eight different isoforms that, in turn, are proteolytically cleaved into combinations of membrane-anchored long forms and soluble short forms. Recent advances highlight how each OPA1 isoform is able to fulfill ...
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(sirolimus), exerting its effect by entering the cell and binding to the immunophilin FK506 tacrolimus)-binding protein 12 Da isoform (FKBP12), forming a complex that binds to the FKBP-rapamycin-binding domain of mTOR, when that protein is part of a multiprotein complex (mTOR complex 1), ...
The mature CD59 protein contains 77 amino acids after removal of the signal sequence and the signal for the GPI-anchor. Its gene is located in the p14-p13 region on the short arm of chromosome 11[66]. CD59 is attached to the cell membrane through a GPI-anchor, instead of having a ...
(study into the nature of the MZ- binding protein is currently underway).14 Importantly, it has been shown that the Z-binding protein has equal affinity for MZ.15 Chemical structure of the macular carotenoids The term carotenoid is used to describe a family of natural organic compounds build ...
The causative agent is thought to be the prion protein, which acquires a pathological isoform through a conformational change and is hardly degradable. Experimental research has identified several substances, which were able to modestly inhibit the formation and propagation of pathological prion ...
Androgens regulate protein synthesis and influence tissue remodeling via the AR, which along with other steroid hormone receptors are members of the nuclear receptor superfamily[36] (Figure 1). As the AR gene is located on the X chromosome (Xq11.2) it exists as a single copy in males. The ...