By extension of this concept, the human-on-a-chip modular microfluidic devices can be built by combining multiple organ chips, where each chip can mimic each part of the human body. Compared with an integrated multiorgan-on-a-chip plate, connecting individual organ chips is more flexible to ...
Protein Proteins are important functional substances found in living organisms, and changes in the structure of proteins modify its original biological activity in the human body. Denaturation of proteins destroy their normal physiological functions, damage cells, and cause disease [74]. In the process...
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6a). SIRT1 protein levels were also upregulated after ω-3 PUFA supplementation (p < 0.05) (Fig. 6b). As SIRT1 is a NAD+-dependent histone deacetylase that affects NAD+ metabolism [24, 38], we also measured the NAD+/NADH ratio to detect SIRT1 activity. Treatment with ω-3 ...
We recognize, however, that mRNA expression is one of multiple factors to be considered when studying the complex molecular networks working simultaneously in tissues. In fact, the ratio between mRNA abundance and abundance of the functional protein coded by the mRNA is hardly 1:1. This has been...
The immature neonatal fecal microbiota substantially impacts the development of gut health and greatly increases the risk of disease. Developing effective strategies to modulate the development of neonatal fecal microbiota has great significance. Herein,
A specimen of the parthenogenetic speciesFolsomia candida. It has a slender, white body shape on average 2.5 mm long. It has a fully developed furca that is used for jumping. The chewing type of mandibula has a molar plate present.F. candidais a euedaphic species, thriving inside the soil...
This reduction in protein or yield can have both a nutritional and economic costs affecting overall human health. To understand the role increased seed size could have on yield and nutritional traits we studied the effects of increased TaBG1 expression in wheat and its role to shape seed size,...
The introduction of the energy difference Δ E between the states will be useful to describe more realistic systems, such as protein domains and other macromolecules of biological origin. Another perspective concerns the consideration of the out-of-equilibrium thermodynamics useful to evaluate the ...
(7.9%, 7/89) were higher in the lumen. Metabolic pathways were also similar in the lumen and serum. The main pathways for which the lumen metabolome had more coverage included protein digestion and absorption, biosynthesis of cofactors, taurine and hypotaurine metabolism, glutathione metabolism, ...