此外,陶娟教授还提到,对于抗PD-1/L1耐药的黑素瘤患者,美国加州大学琼森综合癌症中心的Antoni Ribas教授团队通过抗PD-1与抗CTLA-4单抗的联合治疗,成功逆转了部分晚期黑素瘤患者的耐药性,延长了他们的无进展生存期。这一发现不仅为黑素瘤患者带来了...
2. Monica Khunger et al. Incidence of pneumonitis with use of PD-1 and PD-L1 inhibitors in non-small cell lung cancer: A Systematic Review and Meta-analysis of trial. 2017. 3.RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance ...
A 12V AC to DC converter is an electronic device that changes the voltage of an alternating current power source to a direct current power source. This converter is specifically designed for LED lights, which require a constant DC voltage to function properly. Why do we need a 12V AC to DC...
A 12V AC to DC converter is an electronic device that changes the voltage of an alternating current power source to a direct current power source. This converter is specifically designed for LED lights, which require a constant DC voltage to function properly. Why do we need a 12V AC to DC...
III期NSCLC放化疗后使用度伐利尤单抗可改善生存[4];IMpower010研究证实可切除II-IIIA期NSCLC患者接受辅助化疗后,再使用阿替利珠单抗辅助治疗可改善无病生存率[5]。在PD-L1 TC≥1%Ⅱ-ⅢA期人群中,阿替利珠单抗组的从随机至复发时间优于最佳支持治疗(BSC)组。
Programmed Death-Ligand 1 Immunohistochemistry in Lung Cancer: In what state is this art? Therapeutic antibodies to programmed death receptor 1 (PD-1) and its ligand PD-L1 show promising clinical results. Anti-PD-L1 immunohistochemistry (IHC) ma... Keith,M.,Kerr,... - 《Journal of Thoracic...
This region contains the site of N-glycosylation and is important for mediating antibody dependent cellular toxicity (ADCC). As such, it can have a dramatic impact on the efficacy of immune checkpoint therapy.Goletz et al. (2018) assessed the impact of “Glyco-optimization” on anti PD-L1 ...
What is a service request? A service request is a formal request submitted by an end user to the IT service desk for initiating a service action. Examples are: Request for information (e.g. request for info on cloud storage limits) Request for access (e.g. request to access a document...
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The mucus layer is a very hydrated and complex viscoelastic medium, with MUC2 as its skeleton component. MUC2 cooperates with other components to consolidate the structure of the mucosal barrier and regulate local microenvironment homeostasis. Therefore, it is important to comprehensively analyze the com...