Introduction Hoodia gordonii is a succulent plant from South Africa that has appetite-suppressant properties. (1-3) Hoodia has been used as a dietary supplement, derived by drying the aerial parts of the plant, (3) or as a source of extr... S Holt,TV Taylor - 《Townsend Letter》 被引...
Trial of a preferential phosphodiesterase 4B inhibitor for idiopathic pulmonary fibrosis. N Engl J Med. 2022;386:2178–87. https://doi.org/10.1056/NEJMoa2201737. This phase 2 study shows that BI1015550 is able to reduce FVC decline irrespective of background antifibrotic therapy. Article CAS ...
Thus far, engineering of the sd1 allele is the only verified case of using a semi-dwarf gene to improve lodging in crops (Liu F et al. 2018). Since the extensive use of one gene for breeding could potentially reduce the diversity of crop varieties and hinder genetic improvement, more dwar...
We focused on the estuary region mainly because it is the only way forward to reach the sea for this anadromous species. Moreover, the estuary represents an important feeding ground for juveniles that, based on data from past spawns, stay there for a few months between April and August ...
Under each of these scenarios, past climatic oscillations are seen as the major distal cause of the process and the location of hotspots is seen as intimately linked to the so-called 'glacial refugia'. Under the first scenario, a hotspot would testify to the long-term persistence of ...
In the view of some population geneticists, drift is of quite minor importance save in special circumstances (for example, when an allele frequency is close to zero). In the view of others, the genetic composition of natural populations is substantially affected by drift, whatever the frequencies...
crying is a good example. A man crying in our culture is seen as fairly unusual, whereas a woman crying is seen as much less unusual. On the other hand, a woman beating up someone is taken as quite unusual behavior where it's less unusual for a man. So, we have gender stereotypes,...
CNN-LOH originates either through a homologous recombination event (“gene conversion”), or because the retained chromosome was duplicated either before or after the LOH event. LOH is strongly associated with loss of the wild-type allele in individuals with an inherited cancer predisposition ...
1 Although VWD is expected to affect men and women equally, there are more women diagnosed with VWD because of gynecological-related hemostatic challenges. The real prevalence of VWD has been a matter of debate for many years, ranging from as high as 1.3%, when taking into account ...
A minor portion of the sIL-6R is generated from an alternatively spliced mRNA [50], but limited proteolysis remains the major mechanism by which the sIL-6R is generated [51]. For signal transduction the IL-6R can either be membrane bound (classic pathway) or soluble (trans-signaling pathway...