Asymptomatic SARS-CoV-2 infection is a less important clinical endpoint than is efficacy against mortality. However, if prevention of asymptomatic infection was a surrogate endpoint for efficacy against clinical disease or transmission, this endpoint could allow earlier estimation of the clinically relevant...
Moreover, the differentiation capacity of the engrafted donor BM cells from the old mice is different from that of young donor BM cells; there is a shift in the lymphoid/myeloid ratio of engrafting cells such that the older donor BM cells manifest greater numbers of myeloid to lymphoid cell...
Today, smear microscopy is still used to monitor treatment response and remains useful to predict failing therapy and to guide diagnostic and therapeutic interventions, such as extension of the intensive phase after 4 months for patients treated with the "short MDR regimen" [31]. However, in a ...
Thus, demonstrating the effects of drugs causing adenosine receptor activation or inactivation on specific systems under distinct experimental settings is not sufficient to prove that they can be delivered in a manner that is clinically effective and safe for treating human disease. We discuss the ...
cells, neutrophils, immunoglobulins, and cytokines such as IL-6 and IL-8, as well as an increase in the release of superoxide anion and other byproducts of neutrophil activation [65–67]. Physiologic changes Even in the absence of disease, there is a predictable loss of lung volume with ...
In addition, the tendency to label a disease condition as “asthma” might be greater in some populations (19). One argument that questions the classical hypothesis of the role of hygiene in asthma is based on some pathophysiologic observations. For example, the protective effect is studied ...
However, improving curcumin’s bioavailability is not a trivial task, and careful analysis of effects in brain and on behaviour are required for new formulations because micromolar levels may be deleterious due to curcumin’s well-known capacity to inhibit the proteasome. Moreover, it has been ...
Here, we argue that neopterin and total neopterin, which is the combined value of 7,8-dihydroneopterin and neopterin, could provide a more comprehensive analysis of clinical inflammation than neopterin alone. Keywords: neopterin; inflammation; 7,8-dihydroneopterin; reactive-oxygen species; antioxidant...
Facebook Twitter Google Share on Facebook AcronymDefinition NGALNeutrophil Gelatinase-Associated Lipocalin(protein) NGALNew Guinea Australia Line(est. 1950) Copyright 1988-2018AcronymFinder.com, All rights reserved. Suggest new definition Want to thank TFD for its existence?Tell a friend about us, add...
The Biological Impact of Oxidative Metabolism in Trypanosomatid Parasites: What Is the Perfect Balance Between Reactive Species Production and Antioxidant Defenses?Chapter First Online: 27 October 2019 pp 127–173 Cite this chapter Oxidative Stress in Microbial Diseases ...