Generally, the pathobiology of TBI is composed of two parts: primary injury and secondary injury [3]. The primary injury is the mechanical impact that initiates a cascade of acute brain damage, including skull fractures, hemorrhage, and neuron death. Conversely, the secondary injury triggers a ...
A member of a family of enzymes involved in the citrullination of proteins (that is, the conversion of arginine into citrulline residues). Besides a number of biological functions, citrullination is also thought to generate neoantigens during autoimmune diseases. CARD9 An adapter protein linking immu...
Human granulocytes express a 55-kDa lipopolysaccharide-binding protein on the cell surface that is identical to the bactericidal/permeability-increasing protein. J Immunol 150:253–263. CAS PubMed Google Scholar Weinrauch Y, Elsbach P, Madsen LM, Foreman A, and Weiss J (1996). The potent ...
However, this is not the only way to activate apoptosis in neutrophils. It is recognized that apoptosis pathways can be activated in neutrophils after phagocytosis and ROS production, or during inflammatory processes when molecules such as extracellular matrix proteins (49), lipopolysaccharide (LPS), ...
in cancer and can be classified into anti-tumor (N1) and pro-tumor (N2) sub-populations. The aim of this review is to discuss the varying nature of neutrophil function in the cancer microenvironment with a specific emphasis on the mechanisms that regulate neutrophil mobilization, recruitment and...
is a complex injury that causes the marked brain pathology, disruption of the normal function of the brain, and death. it is an important public health issue considering not only its high mortality rate but also the numerous complications in the patients who survive the injury [1,2], such ...
Glioma is the most common primary intracranial tumor in adults, with high incidence, recurrence, and mortality rates. Tumor-associated neutrophils (TANs) are essential components of the tumor microenvironment (TME) in glioma and play a crucial role in gl
Pneumonic plague is a fatal disease caused by Yersinia pestis that is associated with a delayed immune response in the lungs. Because neutrophils are the first immune cells recruited to sites of infection, we investigated the mechanisms responsible for their delayed homing to the lung. During the ...
. The amounts of neutrophils recruited by the non-aggregative strain were reduced (Fig.2h), showing that the formation of bacterial aggregates enhanced neutrophil recruitment. These data show that bacterial adhesion, amplified by bacterial auto-aggregation, both mediated by type IV pili, is ...
It is also in the recent years that microfluidics-based migration assays were developed, allowing good gradient control25, 26, but being experimentally complex. Assays utilizing surface-bound guiding cues have traditionally been aimed at probing axonal guidance27, 28, but recent attempts have been ...