46It is thought that these neutrophils are retained in the lung actively by upregulation of the chemokine receptor CXCR4, which binds CXCL12, a ligand expressed by a subset of lung endothelial cells.47The role of these resident lung
oral infections 57 . neutrophils can also fail to reach the gingiva due to recruitment defects, such as in ladi. ladi is considered a prototypic neutrophil defect linked to periodontitis. in ladi, neutrophils fail to exit circulation and transmigrate into tissues due to mutations in itgb2 ,...
4e). It is further confirmed that the presence and infiltration of FOXO1high neutrophils in the chronic stage of TBI is involved in TBI-induced depression. Indeed, we consistently and dynamically detected the disruption of BBB and infiltration of FOXO1high neutrophils in certain mice (Additional ...
Neutrophils, the predominant leukocytes in peripheral blood, consistently act as the vanguards of the immune system by eliminating pathogens and inflammatory debris [15]. With the rapid development of high-throughput sequencing technology, subsets of neutrophils have been divided into two sharply contrasti...
It is proposed that the conversion of Met to Met(O) in these proteins predominantly occurs by action of the myeloperoxidase/ H 2O 2/Cl system in the extracellular space.doi:10.1016/0014-5793(88)81401-7I. Beck-SpeierL. LeuschelG. Luippold...
It is noticeable, however, that innate immune cells provide signals for proliferation and activation of T and B cells to initiate adaptive immunity against self-antigens which would cause autoimmune diseases. Importantly, recent findings strongly indicate that neutrophils also act as APCs via direct ...
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The Sal used in this work was the engineered strain VNP20009, which the FDA has approved for clinical research. It has stable proliferative activity and favorable tumor-targeting properties. Transmission electron microscopy revealed the structure of the Sal as a blunt rod shape with an approximate ...
NETosis: how vital is it? Blood 122, 2784–2794 (2013). Article CAS PubMed Google Scholar Roos, D., Voetman, A.A. & Meerhof, L.J. Functional activity of enucleated human polymorphonuclear leukocytes. J. Cell Biol. 97, 368–377 (1983). Article CAS PubMed Google Scholar Malawista...
On the other hand, high concentrations of ROS are toxic to both tumor cells and the host cells, especially the anti-tumor immune cells, leading to tumoricidal and immunosuppressive effects22,24. It is therefore not surprising that ROS blockade showed both inhibitory and stimulatory effects on ...