SSRIs first came onto the market in the late 1980s, with the first of these drugs — fluoxetine (Prozac®) — beingapprovedin 1987 by the Food and Drug Administration (FDA). Compared to other antidepressants, SSRIs havefewer side effectswhile still being effective. SSRIs arebelievedto work...
NSAIDs are drugs that treat pain as well as fevers. Here’s what you should know about how NSAIDs work, possible side effects and risks, and alternatives if you can’t tolerate them.
Because most SSRI and SNRI receptors are found in the central nervous system (CNS), GI tract, and blood vessels, the clinical signs of toxicity with these drugs are neurological, gastrointestinal, and cardiovascular. CNS depression, agitation, tremors, and seizures are the most common signs of ...
Patients received doses ranging from 1 to 3 mg/day or placebo (an inactive treatment), plus an antidepressant (SSRI or SNRI) treatment (ADT). Whencompared to score changes with the placebo + ADT, MADRS total scores dropped by: -1.3 points (with the 1 mg/day + ADT) -2 points (using...
Applying novel trial designs, targeting of pre-symptomatic disease stages, and the acknowledgment of PD heterogeneity raise hopes to overcome past failures in the development of drugs for disease modification. In this review, we address these recent developments and venture a glimpse into the future ...
Where are neurotransmitters synthesized? What drugs mimic neurotransmitters? Is dopamine a hormone or neurotransmitter? Which neurotransmitter is most closely linked to neuroticism? What are the three neurotransmitters that are involved in depression? What causes the release of neurotransmitter molecules? Whic...
There are three main types of medications prescribed to treat anxiety disorders; antidepressants, anxiolytics (anti-anxiety drugs), and beta-blockers. The medication used may depend on the type of anxiety disorder. Both anxiolytics and antidepressants target the balance of neurotransmitters (chemicals...
For what they're worth, here are some suggestions. First, so long as you can afford it, stick with the long, messy business of finding the right drugs for you. Each successive bout of depression I've had has been worse than the one before. Knowing that the next time will be worse,...
Individual characteristics, such as polymorphisms of the gene encoding the 2D6 subunit of cytochrome P450, may affect the metabolism of the SNRI; while, the combination with other drugs may lead to an increased risk of iridocorneal angle closure, and may further exacerbate other mechanisms. ...
Gamma-hydroxybutyrate (GHB) drugs are central nervous system (CNS) depressants. Though their exact mechanism is not fully understood, they seem to affectgamma-aminobutyric acid (GABA)receptors in the brain during sleep, which may help regulate sleep and alertness. ...