In particular, NK cells could be involved in protection against cancer-initiating cells (CICs)[15]. CICs are characterized by slow growth and resistance to drugs and radiation, and play a crucial role in tumor recurrence. Recent data suggest that CICs are more sensitive to NK cells because ...
Scientists have found that some of the mechanisms of action of drugs suitable for MSI-H treatment, such as PD-L1 (programed cell death ligand 1) immunosuppressant, can produce heteroantigens that are easy to be recognized by T cells in dMMR cancer cells, which is beneficial to a variety ...
Cite this: Axel Grothey. Biomarkers in GI Cancers: What to Measure When -Medscape- Jun 17, 2011. Special Coverage:COVID-19 Latest Perspective Guidelines Drugs & Diseases Global Coverage Additional Resources Slideshow Anal Cancer: The Fundamentals...
These numbers require the biggest effort and attention on this cancer in order to investigate its heterogeneity and to maximize treatment outcomes. The biggest challenge for the next future will be to understand which cancer subgroup deserves a specific targeted agent, also reconsidering drugs that hav...
The most promising classes of drugs are the bispecific antibodies (bsABs) and the antibody–drug conjugates (ADCs) [30,71]. BsAB comprises two monoclonal antibodies coupled by a peptide linker, making them able to bind to two different antigens or two different epitopes on the same antigen [...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook LV (redirected fromleucovorin) Dictionary Medical Encyclopedia Wikipedia Related to leucovorin:methotrexate,Oxaliplatin,leucovorin rescue,Leucovorin calcium Category filter: ...
The drugs can be very hard on the body, and it is important to protect the patient's organ systems, to make sure the patient gets adequate nutrition, and to protect the patient's immune system. Aggressive chemotherapy can wipe out the immune system, leaving the patient vulnerable to ...
are instead implanted under the skin in theabdomenand pump chemotherapy drugs directly into the hepatic artery that goes to the liver, concentrating treatment on the affected area and so allowing treatment to be done with lower levels of the drugs and fewer side effects. The surgery to implant ...
Some of these patients will receive systemic anti-cancer therapy (SACT) in the neoadjuvant and adjuvant settings. The majority of patients, usually with locally advanced or metastatic disease, will receive SACT with palliative intent. These treatment options are expanding beyond traditional chemotherapy...