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Popov I,Jelic S,Krivokapic Z,et al.What is the best sequence of chemotherapy in advanced colorectal cancer? Final results of a five-arm study[J].Chemotherapy,2006,52(1):20～22Popov I, Jelic S, Krivokapic Z, et al. W hat is the best sequence of chemotherapy in advanced colorectal ...
Adjuvant therapy provides a non-statistically significant 1% to 5% survival benefit in stage II patients that may reach statistical significance with time, as recurrence risk with adjuvant chemotherapy is clearly reduced. Google Scholar Efficacy of adjuvant fluorouracil and folinic acid in B2 colon ...
Although immunotherapy is not yet routinely used in colorectal cancer, we now know that most treatments used (chemotherapy and biotherapy) have immunomodulatory effects, such as induction of immunogenic cell death by chemotherapy, inhibition of immunosuppression by antiangiogenic agents, and antibody-...
Lynch syndrome is an autosomal dominant tumor syndrome caused by mutations in MMR strains, and it can also cause tumors in other parts of the colon and rectum [4]. Because of the limitation of early MSI detection and the ambiguity of early MSI mechanism, only some specific chemotherapy drugs...
A randomized phase II/III trial comparing hepatectomy followed by mFOLFOX6 with hepatectomy alone as treatment for liver metastasis from colorectal cancer:... A randomized controlled trial is being conducted in Japan to compare hepatectomy alone with hepatectomy followed by adjuvant chemotherapy as treat...
Although a recent meta-analysis showed that there was insufficient data to justify the exclusion of anti-EGFR monoclonal antibodies, antiangiogenic agents should be preferred in the first-line setting. Despite the lack of a randomized phase 3 study dedicated to BRAF-mutated CRC, chemotherapy ...
Don’t tell them that their science-based treatments are bunk and what they really need to be doing is just changing their diet, breathing pure oxygen, or relieving their constipation to be cured of cancer. Do not tell someone who is in the middle of treatment that chemotherapy is ...
In my clinical practice, I have a very pragmatic approach to stage II colon cancer. I try to identify patients at high risk for recurrence and patients at low risk who do not need systemic adjuvant chemotherapy. There is a group in between, the intermediate-risk group, which might require ...
There was a strong consensus for intensified preoperative chemotherapy in all clinical situations for BRAF-mutated LM.Conclusions This national survey provides an overview of the practice patterns in the treatment of LM occurring after adjuvant FOLFOX for primary. It could be a basis to establish ...