Four hours after taking the drug, the ratio of the drug concentration in the cerebrospinal fluid (CSF) to the blood drug concentration is 0.4. This product is metabolized in cells into triphosphate with antiviral activity. After a single dose, the half-life is 1 to 1.5 hours. The ...
adiscuss the metabolism and mechanisms of toxicity of isoniazid, rifampicin and pyrazinamide, and describe risk factors and management of antituberculosis drug- 谈论isoniazid、rifampicin和pyrazinamide毒力新陈代谢和机制,并且描述antituberculosis药物的风险因素和管理[translate] ...
Mechanism of action — Rifampin is thoughtto inhibit bacterial DNA-dependent RNA polymerase, which appears to occur as a result of drug binding in the polymerase subunit deep within the DNA/RNA channel, facilitating direct blocking of the elongating RNA [3]. Is rifampin an antibacterial drug? Th...
months or even years.24,25,33 Although there are some data about the preven- tion of cisplatin neurotoxicity with utilization of vitamin E and amifostine, a Cochrane meta-analysis could not find any beneficial effects of preventive strategies.55 Oxaliplatin is a new type of...
due to inadequate physician prescription and/or patient adherence in some countries or geographical settings.2'3 Programmatic management of drug-resistant tuberculosis to ensure good patient outcome cannot be overemphasised. An additional mechanism at play is the 'exuberant' use of this class of agents...