Is isoniazid an inducer or inhibitor? Isoniazid is amechanism-based inhibitorof cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes. Is fluconazole an enzyme inducer? Fluconazole behaved as ahigh-magnitude inducerand significantly increased cytochrome P-450 concentrations alread...
Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis. Infect. Immun. 65, 1395–1401 (1997). CAS PubMed PubMed Central Google Scholar Gagneux, S. et al. The competitive cost of antibiotic resistance in ...
It took around 21 days of intensive antibiotic therapy to get bacteriological clearance from blood, which signifies the tenacious nature of this infection.Peer Review reports Introduction Melioidosis caused by Burkholderia pseudomallei is often referred to as “The Great Mimicker” because it has a ...
Antibiotic prophylaxis for preventing postorthotopic liver transplant tuberculosis: is there a safe alternative to isoniazid?doi:10.1111/tri.12955DinoTropicalSgarabottoTropicalSilvanoTropicalFasolatoTropicalFabrizioTropicalVianelloTropicalFabioTropicalVittadello...
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In the present study, bifidobacterial rpoβ sequences were analyzed to characterize the mutations that contribute to the development of intrinsic resistance to RIF, isoniazid, streptomycin and pyrazinamide. Sequence variations, which mapped to cassettes 1 and 2 of the rpoβ pocket, are also found ...
Mtb. However, this tolerance could still be blocked by C10, suggesting that C10 functions independently of Rv3161c to influence isoniazid and lysozyme sensitivity. Introduction Tuberculosis (TB) caused byMycobacterium tuberculosis(Mtb) is still a major infectious disease worldwide1. In 2018, an ...
Posttranslational modification of a histone-like protein regulates phenotypic resistance to isoniazid in mycobacteria There is increasing evidence that phenotypically drug-resistant bacteria may be important determinants of antibiotic treatment failure. Using high-throughput imaging, we defined distinct subpopulati...
We reasoned that LPZ may be converted to an active antibiotic primarily in an intracellular environment, thereby explaining the discrepancy between the ex vivo and in vitro activity. Thus, we quantified intracellular LPZ and possible metabolites over a period of 48 h using liquid chromatography–...
A standard course of TB therapy for drug-sensitive Mtb consists of the administration of four drugs for two months, Isoniazid (H), Rifampin (R), Pyrazinamide (Z), Ethambutol (E), and then the continuation of HR for an additional four months, as recommended by the World Health Organization...