Nakagawa S, Fujii T, Yokoyama G, Kazanietz MG, Yamana H, Shirouzu K . Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: involvement of protein kinase Calpha and extracellular signal-regulated kinase mitogen-activated protein kinase.Mol Carcinog2003;38: 106–116....
Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumor
It mainly mediates various physiological functions by regulating protein kinase A’s (PKA) activity. This article will discuss in detail the question “What does cyclic adenosine monophosphate do”. Cyclic Adenosine Monophosphate’s Generation and Degradation Cyclic adenosine monophosphate is generated by ...
Sagata, N. What does Mos do in oocytes and somatic cells? BioEssays 19, 13-21 Mos, a protein kinase, is specifically expressed and functions during meiotic maturation (or G2/M progression) of vertebrate oocytes. When expressed ectopically, however, it can also readily induce oncogenic ...
Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A. J Biol Chem. 2002;277:4247-4254. [PubMed] [DOI] [Cited in This Article: 1] [Cited by in Crossref: 129] [Cited by in F6Publishing: 130]...
Protein kinase A (PKA) or cyclic‐AMP (cAMP)‐dependent kinase was among the first serine–threonine kinases to be molecularly and functionally characterized. For years, it was investigated as the enzyme that mediates cAMP functions in almost all cell systems and organisms studied to date....
What do you know about the molecule Rho-kinase? If you’re like most folk, the answer is “not much.” The facts I’ve uncovered in my research on this very special molecule are concerning. Dr. James K. Liao, a vascular medicine expert at Brigham and Women’s Hospital in Boston, bel...
(a) The protein kinase. (b) The G protein coupled receptor. (c) The second messenger. (d) The effector. Which substance provides the instructions for producing proteins? Describe the process of protein synthesis. Where does it occur? What amino acid forms the N-terminus of the protein?
What is the catecholase enzyme? How is it produced? How does it function? Enzymes act to lower the activation energy of a chemical reaction. How do enzyme do this? What is a substance that reduces the activity of an enzyme by entering the active site in place of the substrate whose stru...
Thus, it is possible that the ADA2a SANT domain, in contrary to the corresponding domain of ADA2b, interacts differently with GCN5 and does not enhance efficiently the binding of the acetyl-CoA to GCN5 as described for the SANT domain of yeast Ada2. Nevertheless, the catalytic activity of...