Figure 1: The phosphorylation of a protein can make it active or inactive. Phosphorylation can either activate a protein (orange) or inactivate it (green). Kinase is an enzyme that phosphorylates proteins. Phosphatase is an enzyme that dephosphorylates proteins, effectively undoing the action of k...
This chapter discusses the recognized substrates for protein kinase C, the relationship between these substrates, and the role of hormones and phorbol esters on cell function. The finding that tumor-promoting phorbol esters can bind to protein kinase C, activating the enzyme and producing the ...
Carbohydrate Metabolism Enzyme Catalysis Enzyme Inhibitors Lipogenesis Protein Structure X-ray Crystallography Xylulose Kinase Introduction “Is life worth living? It all depends on the liver.” (William James). The rising tide of metabolic disease has focused attention on the balance between the body'...
RNA interference is a conserved mechanism that regulates gene expression in response to the presence of double-stranded (ds)RNAs. The RNase III-like enzyme... A Lingel,B Simon,E Izaurralde,... - 《Nature》 被引量: 1275发表: 2003年 Regulation of protein synthesis in mammalian cells: II....
MITOCHONDRIA contain small amounts of DNA which differ in several chemical and physical properties from nuclear DNA (reviewed in ref. 1). Mitochondrial DNA (MDNA) of yeast 2–6 is replicated by a mitochondrial DNA polymerase 7 which is different from the nuclear enzyme. (unpublished results of...
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a stable 3D structure. These regions are structurally heterogeneous, ubiquitous and found across all kingdoms of life. Despite the absence o
Enzyme dynamics have been studied in the context of the amino acid kinase family of enzymes. We have analysed the large-amplitude motions associated to ligand binding process involved in catalysis and allosteric regulation of the activity. By means of elastic network models, we show that the ...
These findings were recapitulated by treatment with MLN4924, an inhibitor of NEDD8-activating enzyme. Furthermore, Shc, an adaptor molecule between antigen receptors and the Ras/Erk pathway, was identified as a target for neddylation. Importantly, mice adoptively transferred with Ubc12 knockdown CD4...
Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain Nathaniel E. Clark, Adam Katolik, Pascal Gallant, Anastasia Welch, ... William G. FairbrotherSeptember 2023 Article 105100 View PDF Article preview select article...
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP ratios. Once activated, AMPK acts to restore energy homeostasis by promoting ATP-producing catabolic pathways while inh...