The production of biopharmaceuticals relies on robust cell systems that can produce recombinant proteins at high levels and grow and survive in the stressful bioprocess environment. Chinese hamster ovary cells (CHO) as the main production hosts offer a variety of advantages including robust growth and...
https://doi.org/10.1016/j.sbi.2021.06.004Get rights and content Under a Creative Commons license open accessAbstract Chromatin in eukaryotic cells is a negatively charged long polymer consisting of DNA, histones, and various associated proteins. With its highly charged and heterogeneous nature, chrom...
CASPubMedGoogle Scholar Masuoka, J., Hegenauer, J., Vandyke, B. R., & Saltman, P. (1993). Intrinsic stoichiometric equilibrium-constants for the binding of zinc(Ii) and Copper(Ii) to the high-affinity site of serum-albumin.Journal of Biological Chemistry,268(29), 21533–21537. CASPub...
The complex formed by IL-6 and its receptor in turn activates a homodimer of the signal transduction beta-receptor gp130 with high affinity [44]. The gp130 receptor thereupon dimerizes and initiates intracellular signal transduction by activating the JAK/STAT and ras/MAP kinase pathways [45]. ...
Although the overall effect of the mutations is not yet known, the high transmission rate of UK iB1.1.7 in the UK may result from the increased affinity of the N501Y mutation to ACE2. In fact, a recent computational analysis predicts that the N501Y mutation likely results in an increased ...
An alternative approach may be to usesst5ligands, considering the high expression ofsst5in corticotropic adenomas. Pasireotide (SOM230) is a recently developed multi-receptor ligand somatostatin analog. Whereas octreotide and lanreotide have high affinity forsst2and modest affinity forsst5, pasireotide...
The long fibrillar collagen structure can hold abundant water due to its shape (large surface area with high water affinity), yet it has been postulated that collagen is fibrillar because the bound water provides structure throughout this length. This is due to the observation that collagen type...
The aim of these ingredients is to enhance the sensory experience of the animal, particularly the umami T1R1 and T1R3 taste receptors, as cats are known to have a strong affinity for umami compounds [50,97]. In the pet food industry, animal protein hydrolysates have been used to create ...
IL-1, on the other hand, does not really damage the cells or induce apoptosis on its own, though it can enhance the harmful effects of TNF-α. While IL-1 receptor blockers (IL-1r β) attach to the IL-1 receptor, they do not activate it; they tend to act as IL-1 antagonists ...
They bind with a 1 to 1 ratio to serum PCSK9, inhibiting PCSK9′s affinity to bind to the LDL-R. The intrahepatic accumulation of the LDL-R favors the clearance of the LDL-C particles, leading to their reduction [153]. PCSK9 inhibitors may also be beneficial in the treatment of ...