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H2A/H2B binding regions. The latter would increase affinity. Such an effect would be consistent with the previously reported patterns of nucleosomal DNA sequence periodicities40,41,42. We further note that these parameters become subordinate to other criteria in subsequent rearrangements of nucleosome po...
et al. A22 disrupts the bacterial actin cytoskeleton by directly binding and inducing a low-affinity state in MreB. Biochemistry 48, 4852–4857 (2009). Article CAS PubMed Google Scholar Laine, R. F., Arganda-Carreras, I., Henriques, R. & Jacquemet, G. Avoiding a replication crisis in...
Given concerns regarding possible cytotoxicity through ABCA1-independentlipidefflux, additional peptide mimetics have been engineered[26]. Peptides comprised of twenty-two amino acids based on domains ofapolipoproteinA-I that have a higher affinity forABCA1have been shown to promote chole...
Glucocorticoid receptors are the ubiquitous low-affinity receptors known to bind to glucocorticoids, a group of steroid hormones that freely cross the blood–brain barrier and are known to play an important role in stress responses, learning, and memory. Previous studies have shown that long-term ...
Schwartz M: The adsorption of coliphage lambda to its host: effect of variations in the surface density of receptor and in phage-receptor affinity. J Mol Biol. 1976, 103: 521-536. 10.1016/0022-2836(76)90215-1. Article CAS PubMed Google Scholar Streisinger G, Owen J: Mechanisms of spo...
Combining these three theories, allowed us to show that due to the higher affinity of microplastics for the hexane (OCA = 0°), the solid pollutants aggregate better in oil than in the aqueous phase where microplastics tend to disperse. Superhydrophobic/superoleophilic surfaces produced as ...
(Complete, Roche Diagnostics, Penzberg, Germany). Depletion of 6 of the most abundant proteins including albumin, transferrin, haptoglobin, alpha-1-antitrypsin, IgA and IgG was performed using the Agilent Multiple Affinity Removal System (Agilent Technologies, Waldbronn, Germany). Blood samples to ...
RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is required for downstream ssDNA transactions. How ultrahigh-affinity binding and dyn
The V2 tail was originally added given its high affinity for β-arrestin2 and for its ability to stabilize the interaction between a given receptor and the recruited arrestin; this addition is indispensable for those of low-affinity or for transient β-arrestin recruitment at many GPCRs. The ...