To our knowledge, no study has applied the multi-omics approaches to endometriosis MenSCs. This is a case-control study at a university-affiliated hospital. MenSCs transcriptome and proteome data were obtained by RNA-seq and UHPLC-MS/MS detection. Among the differentially expressed proteins and ...
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synthesis of essential proteins by targeting cell organelles and aggregates of long-lived proteins for degradation and recycling. However, it may also result in autophagy-associated cell death [88]. The proteins LC3B-II, Beclin I and ATG7 are essential for the latter. Beclin-1 possesses a BH3...
However, a more recent report argues that they are only observed under particular conditions (in the presence of bovine serum albumin (BSA) and dithiothreitol (DTT)) [23] and that chromatin condensates appear to have a solid-like feature at a micron-scale. The physical properties of chromatin...
Regrettably, this approach does not recognize that changing the intake/availability side of the energy balance equation will invariably result in metabolic and/or behavioral changes on the energy expenditure side. When dieting, the magnitude of the initial energy deficit is diminished over time as ...
Despite using a partially purified NtcA protein (Supplementary Figure S2A) no shift was detected when the non-specific competitor was used, an indication that the contaminating proteins do not have DNA-binding activity. The specificity of the interaction was further tested using a DNA fragment of...
To the best of our knowledge, the only tBLMs allowing the functional activity of proteins to be directly monitored by measuring the protein-induced ion flow across the lipid bilayer are mercury-supported tBLMs [3,4,10]. Thanks to its liquid state, mercury provides the lipid bilayer with a ...
Parkin, which is featured by its RING1-in-between-ring (IBR)-RING2 domains, is a ring-in-between-ring (RBR) E3 ubiquitin ligase to ubiquitinate multiple OMM proteins [49]. Afterwards, some adaptor proteins, such as p62, recognizes the poly-ubiquitinated mitochondrial OMMs and targets them ...
histolytica trophozoites enhanced parasite survival in response to oxidative stress and markedly increased the level of the EhPTPA protein. However, a clear role for amoebic functions was not specified, mainly because the overexpression of both proteins decreased the trophozoite's motility and, in ...
Interestingly, ORF2 and ORF3 proteins in cell lysate and cell supernatant migrated differently, indicating that these proteins likely undergo post-translational modifications during secretion. 7. Clinical The course and clinical presentation of HEV infection is highly variable (Figure 3); the mechanisms...