Activated mast cells release proteases, e.g., tryptase, which may functionally impact tendon cells or activate nearby nerves. Mast cells also release NGF, which moreover stimulate upregulation of pain-receptors (e.g., NMDR1) as well as pain mediators (e.g., SP, glutamate) on peripheral ...
feasible if an unbiased design-based stereology approach such as the physical or optical disector is applied (Sterio1984; Hsia et al.2010; Gruber et al.2012). Using an assumption-based quantitative approach and the mean cell diameter across the nucleus as surrogate for cell size, hypertrophy w...
Among these, high levels of CD117 (c-kit) are correlated with increased proliferation and activation of mast cells in these patients, as well as high levels of tryptase reflecting disease progression or high levels of chymase (an index of fibrosis and remodelling) reflecting the state of ...