Receiving CAR-T cell therapy can take a few weeks as a patient's T cells, which normally help fight off infections, are collected and genetically engineered to target lymphoma. After low-dose chemotherapy, the modified cells are infused back into the patient. These cells can then attack and ...
CAR T cells for infection, autoimmunity and allotransplantation Chimeric antigen receptors (CARs) have shown remarkable ability to re-direct T cells totarget CD19-expressing tumours, resulting in remission rates of up t... CR Maldini,GI Ellis,JL Riley - 《Nature Reviews Immunology》 被引量: 8...
Tregs are a subset of mature T cells with regulatory function, which play an important role in maintaining self-tolerance and regulating the overall immune response to infection or tumor cells. Tregs can inhibit the activation, proliferation and function of immune cells such as CD4+and CD8+T cel...
CAR T cells — what have we learnt?doi:10.1038/nrclinonc.2017.196NoneNat Rev Clin OncolNature Reviews Clinical Oncology
I'm sorry, Mr Jones hasn't come back for his business trip. The car factory is a big employer in the area. Can you believe the mags. Can you believe the magazine sells seven thousands copies a month. A lawyer has been hired to handle the case. Do you know how much the house is...
A. The latest estimates suggest that nearly one in nine individuals do not have enough to eat between 2014 and 2016. B. Projections indicate that the 2015 MDG target is nearly reached, with 12.9 per cent of undernourished population.
How does immunotherapy target cancer? Traditional cancer treatments that are focused on eliminating cancer cells, like radiation therapy and chemotherapy, can have debilitating physical and emotional side effects and often have limited success with metastatic cancers. These types of treatments also do not...
The studies of cell types and evolution/development (Evo-Devo) are truly interdependent; to achieve meaningful progress, one cannot just do one without the other. Finally, to put all these together, we need a conceptual framework and knowledge base to organize all the knowledge gained from ...
There are some kinds of interference that you can’t do anything about, short of physically changing your location.Obstructions to cell signalinclude natural terrain like tress or mountains, plus man-made obstacles likemetalor other modern building materials. If you’re in arural or remotelocation...
Last, but not least, animal studies showed also that the female heart is equipped with a larger pool of functionally competent human cardiac stem cells, younger myocytes, and a faster myocyte turnover than the male myo- cardium may influence the tendency toward a specific form of ventricular ...