Protein binding is negligible. This product can penetrate the blood-brain barrier. Four hours after taking the drug, the ratio of the drug concentration in the cerebrospinal fluid (CSF) to the blood drug concentration is 0.4. This product is metabolized in cells into triphosphate with antiviral ...
Mechanism of action — Rifampin is thoughtto inhibit bacterial DNA-dependent RNA polymerase, which appears to occur as a result of drug binding in the polymerase subunit deep within the DNA/RNA channel, facilitating direct blocking of the elongating RNA [3]. Is rifampin an antibacterial drug? Th...
adiscuss the metabolism and mechanisms of toxicity of isoniazid, rifampicin and pyrazinamide, and describe risk factors and management of antituberculosis drug- 谈论isoniazid、rifampicin和pyrazinamide毒力新陈代谢和机制,并且描述antituberculosis药物的风险因素和管理[translate] ...
settings.2'3 Programmatic management of drug-resistant tuberculosis to ensure good patient outcome cannot be overemphasised. An additional mechanism at play is the 'exuberant' use of this class of agents in the treatment of community-acquired bacterial infections, in particular respiratory infections. ...