Over the past decade, cancer stem cells have emerged as the centerpiece of cancer research, having a major role in resistance to conventional therapy and in the metastatic spread of tumours. The authors discuss the biological complexity of this subpopula
Dynamic selection of a range of cells in excel using powershell Dynamic Where-Object Filter Dynamically create folders for move-item content Dynamically populate powershell switch statement E-mail notification when VM is shutdown and when is back up and running Easy way to download updates from Up...
Conversely, medullary thymic epithelial cells (mTEC), which can support negative selection of thymocytes responding too strongly to self, do not express the β5t-proteasome subunit and, instead, predominantly rely on the constitutive proteasome and immunoproteasome to generate their MHC I-bound peptide...
Phenotype switching between the cancer stem-cell state, here XHigh (where X can be one of the stem-cell markers, such as CD117, MDR1, CD44, ALDH1; Hanahan and Weinberg, 2011; Medema, 2013), and the more differentiated, here XLow, state epitomises non-genetic plasticity of cancer cells...
from CD4+CD8+double-positive (DP) thymocytes. In fact, majority of NKT cells branch out from the conventional development of T cells in the CD4+CD8+DP step [51]. These cells express surface molecules of both T cells (such as TCR and CD3) and NK cells (such as NKG2D and CD161), ...
Cancer stem cells are, however, in many aspects very similar to normal stem cells. They apparently express the same markers as normal stem cells. Therapies aimed at cancer stem cells therefore have a new problem: how to target cancer stem cells and leave normal stem cells intact? Or, in ...
[35]. Although slower, the translocation itself is reminiscent of GLUT4 trafficking in muscle cells or adipocytes in response to insulin signaling and demonstrates that surface expression of GLUT1 can also be regulated. Interestingly, SCs do express insulin receptors, which modulate the production of...
Human transferrin (TF) Receptor, an iron-binding protein to transfer iron absorbed via the digestive tract and iron released by red blood cell degradation into bone marrow in the form of the TFR-Fe3+ complex to generate mature red blood cells and transporting iron into cells that express TFRs...
TsiRveeg cells. Another mechanism tissue damage following of counteracting virus infection exces- is the induction, activation or expansion of several types of TfuRnegccteiolln, the of main other activity cell typ cells are CD4+ T cells that of which is to inhibit the es. The express bthee...
Although CTA-specific T cells are less likely to express high level of activation-induced IRs,37,38,39 some of them can demonstrate upregulation of germline-like IR expression, such as CD94/NKG2a with compromised antitumor activity.40 Exploring how to improve antitumor activities of CTA-specific...