cells of the obese and elderly prior to infection can explain not only the vulnerability of these two demographic groups towards development of a severe infection with SARS-CoV-2, but also the observed cytokine response in these vulnerable patients, which is skewed towards pro-inflammatory cytokines...
From blood storms to honeycomb lungs, here’s an organ-by-organ look at how COVID-19 harms humans.
In late 2020, COVID-19’s global death toll was rising as cold weather in the Northern Hemisphere and holiday gatherings spurred rapid transmission of SARS-CoV-2 in the absence of a vaccine. Scientists and public-health officials were desperate for new ways to track the virus, which often ...
Fig. 2. Mechanism of infection of the SARS-CoV-2 in human cells. The SARS-CoV-2 S protein binds with the ACE2 receptor on the host cell and is subsequently cleaved at the S1/S2 and S2′ sites by the TMPRSS2 protease. This activates the S2 subunit and leads to a fusion between th...
(ACE2+) Cells in the SARS patients51. The increased levels of these cytokine might not only result in acute lung injury, but also be associated with psychiatric disorders, such as depressive disorders, bipolar, or anxiety disorders52,53. In this study, patients aged 45–64 years or≧65 ...
Like other coronaviruses, SARS-CoV-2 particles aresphericaland have proteins called spikes protruding from their surface. These spikes latch onto human cells, then undergo a structural change that allows the viral membrane to fuse with the cell membrane. ...
The laboratory test data showed that the percentage of neutrophils and the level of LDH is higher, and the number of CD4+ and CD8+T-cells is decreased in children's COVID-19 cases. Conclusion Based on these early observations, as pediatricians, this review put forward some thoughts on ...
SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally, vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. ...
What is the disease that infects the red blood cells of the circulatory system? What is the application of nanobio in treatment of infectious disease? What is a pandemic? A) An acute disease. B) A toxic disease. C) A viral disease. D) A global disease. ...
Since SARS-CoV-2 infects through the angiotensin-converting enzyme 2 (ACE2) receptor, which is also expressed by endothelial cells, the article investigates the possibility of SARS-CoV-2 direct infection to the endothelial cell of vascular beds of different organs The Lancet, 395 (10234) (2020...