In this review, the pathways of misfold and aggregation of a protein are accessed along with the primary causes that turn a native soluble protein into amyloid fibrils or native-like aggregate. In addition, an insight into the biophysical and biochemical aspects fundamental to amyloid fibril ...
Insights into mortality patterns and causes of death through a process point of view model Process point of view (POV) models of mortality, such as the Strehler鈥揗ildvan and stochastic vitality models, represent death in terms of the loss of sur... James J. Anderson,Ting Li,David J. S...
Heat can be used to disrupt hydrogen bonds and non-polar hydrophobic interactions. This occurs because heat increases the kinetic energy andcauses the molecules to vibrate so rapidly and violently thatthe bonds are disrupted. The proteins in eggs denature and coagulate during cooking. What is protei...
While the exact causes and mechanisms are not fully understood, leading to the situation can only be managed but not cured. The microbiota with many residing on the skin and mucosal surfaces of the host body in a symbiotic relationship. In recent years, research has shown a significant link ...
Several monogenic causes for PD have been identified (Blauwendraat et al. 2020). These findings have for example implicated dysfunction of mitophagy and autophagy in the pathogenesis of PD (Nguyen et al. 2019; Singleton and Hardy 2019). Mendelian PD is thought to potentially serve as a model...
This has led to the identification of several pathways that impinge on the ageing process, fortifying a multifactorial hypothesis to explain the underlying causes of organismal ageing. Hutchinson–Gilford progeria syndrome (HGPS) and other human progerias allow researchers a unique glimpse at the ...
About 8% of lung cancers are thought to be inherited or linked to gene changes, but smoking and air pollution remain the primary causes of lung cancer. Continue reading How aggressive is non-small cell lung cancer? Non-small cell lung cancer (NSCLC) tends to spread more slowly than small...
What type of mutation causes ataxia telangiectasia? What is the etiology of emphysema? What is the underlying disease process in cystic fibrosis? What is the difference between etiology and pathogenesis? What are the symptoms of Cockayne syndrome? What is an eosinophilic disorder? What is a chronic...
The most common cause of dementia is Alzheimer’s disease, though there are many other causes, including vascular dementia, Lewy body dementia, frontotemporal dementia, and others.DementiaDementia is a significant and growing healthcare problem as more of the population is living lon...
Nematocyte and battery cell complex anatomy.ASchematic of the stenotele nematocyte discharge process. Mechanical and chemical stimulation of the cnidocil on the nematocyte cell surface (not pictured) causes nematocyst discharge in two phases. In the first phase, the stylet is rapidly ejected. In ...