Heart failure.Your doctor should monitor you closely while you are taking TZDs with Apidra. Get emergency medical help if you have: Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion. ...
For TZDs, switching was slightly inferior to continuing therapy unchanged, and for DPP4 inhibitors, switching was substantially better than continuing. However, for each of the three classes (sulfonylureas, TZDs, and DPP4 inhibitors), adding another medication lead to the greatest HbA1c reduction, ...