Thus, the shortcomings of AF2 can fall into three categories: (1) cases where low to moderate confidence regions display incorrect secondary, tertiary, or quaternary structures; (2) examples of backbone structure side chain rotamer or individual domain structures are accurate but misaligned relative ...
The other examples in this category of survivin inhibitors are those that disrupt survivin interactions with Smac (also called DIABLO in mice) to induce apoptosis and cancer cell death. Several early studies indicated the importance of survivin-Smac interactions for cancer cell survival [12,13,14,1...
Lifestyle interventions aimed at weight loss are key to the management of NAFLD (Figure 2) and fall under the following two main categories: increased physical activity and diet. Increasing physical activity on its own, including both aerobic and resistance exercise, can reduce liver fat content ...