The CRISPR system is the basis of adaptive immunity in bacteria and archaea. It utilizes Cas nucleases, which are enzymes that can bind and create double-stranded breaks (DSBs) in DNA. When a bacterium is infected by a virus, it uses a Cas nuclease to snip off a piece of viral DNA kno...
The gut microbiome (GM) has been implicated in a vast number of human pathologies and has become a focus of oncology research over the past 5 years. The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug metabolism, maintenance of structural integrity ...
Given the ongoing advances in understanding the pathogenesis of AD, there are novel targets for pharmacological intervention. We are now in an unprecedented time with more than 40 topical treatments in the pipeline for AD in addition to many developments and treatments on the horizon. This review ...
Antimicrobials are substances that are responsible for killing microbes or pathogens and thus halting their growth. Antimicrobials are classified based on the microbes against which they act, such as antifungals used against fungi.Answer and Explanation: Important properties for the selection of ...
It is rare for the heart to become infected with bacteria, so people who have a damaged or diseased heart, either due to a pre-existing condition or past surgeries, are most at risk of getting IE.4For these individuals, the bacteria can more easily enter the heart, and since white blood...
5 JL Martínez, F Rojo, J Vila Are non‐lethal targets useful for developing novel antimicrobials? Future Microbiol (2011) in press. Google Scholar 6 MJ McConnell, J Pachón Active and passive immunization againstAcinetobacter baumannii using an inactivated whole cell vaccine Vaccine, 29 (2011), ...
they have evolved along with human evolution as a community. Additionally, we learned from experience the health advantages of herbal products; for example, ayurvedic medicines are in the main nutraceuticals, which again suggest their starting point around 5000 BCE and are still commonly used [16]...
This has led to international targets which have cascaded down to local and sector-specific action. The European Union (EU) laid out aims in 2019 that all antibiotic use within the sheep sector should be recorded, country by country, by 2026, and for all livestock sectors and companion ...
therapy. The institution of more accessible therapeutic drug monitoring will help to optimize drug administration and support a patient-specific approach. Areas where further research is required are investigation into the heterogeneity of critically ill patients and the need for new antibacterial drug ...
Not surprisingly, the impact of RDTs on patient care and outcomes has been most comprehensively studied in positive blood cultures. The goal of early provision of organism identification and antimicrobial susceptibility status is earlier optimization or discontinuation of antimicrobials. This, in turn, ...