The administration of antimicrobial peptides alone or in combination with antibiotic agents thus represents a novel strategy in the antiinfective treatment with potentially important beneficial aspects. Here, data are presented which describe immunological and clinical aspects of the use of antimicrobial ...
Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines. Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines.The first barrier that an antimicrobial ... - 《Current Drug ...
Vovis - 《Antimicrobial Agents & Chemotherapy》 被引量: 148发表: 1999年 Basic Microbiological Techniques Used in Antibacterial Drug Discovery In vitro assessment of activity is crucial to the development of antibacterial agents. Several basic clinical microbiology procedures for this evaluation a... M...
As fatty acid synthesis (FAS) in bacteria is an essential process for cell survival, the enzymes involved in the FAS pathway have emerged as promising targets for antimicrobial agents. Several lines of evidence have indicated that bacterial condensing enzymes are central to the initiation and ...
Antimicrobial stewardship programs (ASPs) are recommended to optimize antimicrobial use for hospitalized patients. Although mechanisms for the implementation of ASPs have been described, data-driven approaches to prioritize specific conditions and antimicrobials for intervention have not been established. We ai...
Metals have been used as antimicrobial agents since antiquity, but throughout most of history their modes of action have remained unclear. Recent studies indicate that different metals cause discrete and distinct types of injuries to microbial cells as a result of oxidative stress, protein dysfunction...
Antimicrobial agents are the cornerstone of therapy against CAP, but there are some novel antibiotic and nonantibiotic therapies that have been recently tested that may potentially impact outcomes of patients with severe CAP. We will review the most recent data regarding novel therapies in patients ...
Another group of antimicrobial agents (Parabens) has been reported to affect MscL as assayed by patch-clamp analysis, but there have been no in vivo studies to determine any MscL-dependent effects. Parabens affect MscS as well as MscL,24,25 suggesting that they are nonspecific activators of ...
Antimicrobial activity MICs were determined by a standard agar dilution method recommended by the Japan Society of Chemotherapy.18 The bacteria were incubated in a Mueller– Hinton agar (Difco) at 37 1C for 18 h, while yeast was incubated for 42 h. Surface plasmon resonance measurements The ...
Determination of antimicrobial activity Selection of potential drug targets for in vivo validation was mainly based on their novelty, that is, they have not been described as targets to existing antimicrobials. Commercial availability of inhibitory compounds without resorting to customized chemical synthesis...