iTregs, which are mainly found in mucosal sites and chronic inflammatory tissues [21, 22], function by releasing soluble cytokines and have the potential to redifferentiate into Th17 cells and express IL-17 [23, 24]. Molecules associated with regulatory T cells The immunosuppressive function of ...
iTregs, which are mainly found in mucosal sites and chronic inflammatory tissues [21, 22], function by releasing soluble cytokines and have the potential to redifferentiate into Th17 cells and express IL-17 [23, 24]. Molecules associated with regulatory T cells The immunosuppressive function of ...
Dendritic cells (DCs) are professional antigen-presenting cells that play a crucial role in the priming and differentiation of CD4+ T cells into several distinct subsets including effector T helper (Th) 1, Th17 and Th2 cells, as well as regulatory T cells (Tregs). It is becoming ...
ILC1, ILC2 and ILC3 represent the three main subsets of helper innate lymphoid cells (ILCs) that can be considered the innate counterparts of CD4+T helper 1 (TH1), 2 (TH2), and 17 (TH17) cells, respectively. ILCs contribute to the regulation of both the innate and adaptive immune sys...
Development of novel cytokine-directed therapies remains complicated as cytokine networks are complex and individual cytokines may have diverse and even opposing functions in different clinical scenarios [81]. The MABINGO study would have clarified what relevance IL-17 or Th17 cells really play in MS...
Regulatory T cells and autoimmune hepatitis: What happens in the liver stays in the liver. Oo Y H,Adams D H.Regulatory T cells and autoimmune hepatitis:What happens in the liver stays in the liver-Journal of Hepatology[J].J Hepatol,2014,... DH Adams,HO Ye - 《Journal of Hepatology ...
A Chinese study group has recently discovered that oxidative stress induces Treg cell apoptosis in mice with fatty livers[48] and subsequently has found also that Th17 cells are increased in the liver of animal and human NASH models[49]. Kupffer cells (KC) are liver macrophages involved in ...
Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis J Immunol, 186 (4) (2011), pp. 2672-2680 Feb 15Epub 2011 Jan 19 CrossrefView in ScopusGoogle Scholar [104] J.P. Mear, K.L. Schreiber, C. Münz, X. Zhu, S. Stevanović...
A similar inflammatory response is observed in COVID-19 patients as well, where low CD4+ T cell counts are seen together with a disproportionally high number of Th17 cells. As mentioned previously, one characteristic of the cell-mediate response during aging is decreased IL2 production and ...
Activated CD4 T cells modulate the antitumor immune response. They differentiate into different cell subgroups: The Th1 response allows secretion of cytokines that promote the antitumor response, as IL-2 or IFNγ, whereas the Th2 response favors tumor growth. The Th17 subset secretes large amounts...