To evaluate the participation of Th17 cells in AD, we successfully detected circulating lymphocytes intracellularly positive for IL-17 by flow cytometry, and the IL-17+ cell population was found exclusively in CD3+CD4+ T cells. The percentage of Th17 cells was increased in peripheral blood of ...
结论 Th17细胞及IL-17可能在 SLE发病过程中发挥作用,以二者为靶向的治疗具有应用前景。 [关键词]系统性红斑狼疮;Th17;白介素-17;发病机制 [中图分类号]R593.241[文献标识码]A[文章编号]2095-3402(2014)01-028-03 TheroleofTh17cellsandinterleukin17inthepathogenesisofsystemiclupuserythematosus HUANGZhi-fang,...
The role of Th17 cells during development of autoimmune diseases has largely been described over the past few years[7,11]. The involvement of Th17/IL-17 pathway during the pathogenesis of rheumatoid arthritis (RA)[12,13] led us to summarize, in this review, signals leading to the ...
The significance of Th17 cells and interleukin- (IL-)17A signaling in host defense and disease development has been demonstrated in various infection and autoimmune models. Numerous studies have indicated that Th17 cells and its signature cytokine IL-17A are critical to the airway's immune response...
Additionally, The role of Th17 cells in malignancy is currently under intense discussion. Despite the rapid expansion in investigating their role in autoimmunity and inflammation, their activities in cancer remain largely unknown [5], [6]. In this review, it is discussed how IL-17 and Th17 ...
Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus. Clin Immunol (Or- lando, Fla). 2014;154(1):1-12. doi:10.1016/j.clim.2014.05.004.J.C. Martin, D.L. Baeten, R. Josien, Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus, Clin. Immunol. 154...
Th17 cells, distinct from Th1 and Th2 cells, secrete cytokines such as IL-17, IL-21, IL-22, and IL-26 [151]. Th17 cells play a crucial role in autoimmune conditions and tumorigenesis, promoting inflammation in various pathological conditions. They can activate Th cells and DCs, induce and...
understanding of the role of bacterial endotoxins and other pathogenic factors in the induction of autoimmune diseases by Th17 cells, CAM practitioners will be able to design CAM therapies targeting IL-17 activity. Targeted therapy can restore the integrity of the intestinal and blood-brain barriers ...
TH17 cells in the big picture of immunology. The pathogenesis of chronic inflammatory diseases is assumed to depend on activated T cells interacting with resident tissue cells or migratory inflammator... C Schmidtweber,M Akdis,C Akdis - 《Journal of Allergy & Clinical Immunology》 被引量: 1058...
tumor. The therapeutic effect of Th17 cells is associated with IL-17 and is mediated by Th17-stimulated CD8 CTLs and other inflammatory leukocytes recruited into B16 melanoma via Th17-stimulated CCL20 chemoattraction. Taken together, our data elucidate a distinct role of Th17 and Th17-stimulated ...